Quercetin for COVID19?

Quercetin is a great flavonoid for many reasons: It’s a known anti-histamine. It’s considered essential in anti-aging protocols. It modulates DNA methylation and epigenetic expression. It also may drop blood cholesterol through inhibition of PCSK9. McGill scientists looking at quercetin’s ability to lower cholesterol are also looking at it as a potential antiviral agent. A study is now underway in China looking at quercetin and COVID19. While there are online resources recommending quercetin now, and you may choose to prescribe it to your COVID19 patients or for prevention, know that outcome of the COVID19 trial will not be available for months.

Author: Kara Fitzgerald, ND

https://www.drkarafitzgerald.com/

Kara Fitzgerald, ND, received her doctor of naturopathic medicine degree from the National University of Natural Medicine in Portland, Oregon. She completed the first Counsel on Naturopathic Medicine-accredited post-doctorate position in nutritional biochemistry and laboratory science at Metametrix Clinical Laboratory under the direction of Richard Lord, PhD. Her residency was completed at Progressive Medical Center, a large, integrative medical practice in Atlanta, Georgia. Dr. Fitzgerald is the lead author and editor of Case Studies in Integrative and Functional Medicine and is a contributing author to Laboratory Evaluations for Integrative and Functional Medicine and the Institute for Functional Medicine (IFM)’s Textbook for Functional Medicine. With the Helfgott Research Institute, Dr. Fitzgerald is actively engaged in clinical research on the DNA methylome using a diet and lifestyle intervention developed in her practice. The first publication from the study focuses on reversal of biological aging and was published 04-12-2021 in the journal Aging. She has published a consumer book titled Younger You as well as a companion cookbook, Better Broths and Healing Tonics and has an application-based Younger You Program, based on the study. Dr. Fitzgerald is on the faculty at IFM, is an IFM Certified Practitioner and lectures globally on functional medicine. She runs a Functional Nutrition Residency program, and maintains a podcast series, New Frontiers in Functional Medicine and an active blog on her website, www.drkarafitzgerald.com. Her clinical practice is in Sandy Hook, Connecticut. Additional publications

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5 Comments

Remy says:

March 25, 2020 at 9:45 am

Something to consider: “The flavonoid quercetin has been demonstrated to inhibit transport of ascorbate by SVCT1. Ascorbate transport by the low-affinity, high capacity SVCT1 can be inhibited by as much as 80% in the presence of quercetin, and 100% when sodium was replaced by choline. Please be aware of this important conflict [98]. Quercetin occurring naturally in foods such as onions should not pose an issue as the amounts are not high enough in an average serving to exert true inhibitory effects. Supplementation of quercetin may need to be reconsidered when using oral ascorbic acid during COVID-19 treatment.”

https://www.evolutamente.it/covid-19-ards-cell-free-hemoglobin-the-ascorbic-acid-connection/?fbclid=IwAR3KzUOfzt8fmwEjS2vB-8ESmXxwZ_bUI8nr1vYGiCFAiVOqBokzlFGdJu0

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- Kara Fitzgerald, ND says:
  
  March 26, 2020 at 9:31 am
  
  Interesting. That quote is from a blog referencing an old cell and animal study paper. I wouldn’t change my use of quercetin based on those findings at all. But if someone felt particularly anxious about the concurrent use of quercetin and vitamin C, since the study identified the inhibition as short term (ie reversible), one could simply space the two nutrients out. Quercetin is a pretty impressive flavonoid for many reasons, antiviral (and perhaps anti-COVID19- human study happening now) properties being just one. I appreciate you posting this idea, Remy. DrKF https://www.jbc.org/content/277/18/15252
  
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Stephanie says:

March 26, 2020 at 1:37 pm

Hello,
You mentioned quercetin for PREVENTATIVE measures of Covid-19.
I have alot of family members on the front line. What is your recommended dose of it for this purpose?
Is it also suitable for children?
Thankyou
Stephanie

Reply
- Kara Fitzgerald, ND says:
  
  March 26, 2020 at 2:46 pm
  
  Good question, Stephanie. Of course, it’s never been researched as a preventative against COVID19. I would comfortably suggest considering 500mg to 1000mg per day. Perhaps dosing higher with symptoms. We use up to 3000mg- 5000mg for a 1-2 week loading period at the beginning of allergy season, dropping down to a maintenance schedule of 500mg-2000mg after symptoms abate. DrKF
  
  Reply
Edgar Villagran says:

May 28, 2020 at 12:35 am

Now I am taking instead Quercitin EGCG its said that is more potent than Quercitin

What dose do you recomend for a try to have a Covid19 profilaxis??

I am also taking n-acetyl l-cisteine and zinc. Also with an multivimin

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Dr. Fitzgerald’s book is an extraordinary integration of a vast amount of diverse information that makes practical sense of the complex interplay between our genes, the folate/vitamin B12 cycle, homocysteine, and the clinical importance of methylation.

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The nutrition methylation webinar has fabulous information on methylation and specific nutrients that are required to support the process. I think I can speak for our team of dietitian nutritionists in saying that it is valuable to connect the science and biochemistry from Dr. Fitzgerald’s point of view with the nutrition and implementation from Romilly. They are a knowledgeable team! I love that this is a food-first approach with an emphasis on food and dietary intervention for sustainable long-term nutritional support. Food is not just medicine, it’s information for methylation and you can’t supplement your way out of a bad diet!

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I enjoyed the presentation and really appreciated the food first approach. There were many talking points to help solidify this concept with patients, particularly those that don’t “buy in” to the food first approach or simply want to take a supplement.

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Dr. Kara Fitzgerald always produces clinically relevant and compelling cutting-edge content in her blogs, PodCasts and newsletters and I try to never miss one. Her dept of knowledge in the functional medicine paradigm and its relevance to modifying the course of the chronic disease epidemic is not only valuable, but inspiring. She is a respected colleague and I always appreciate the effort she puts into keeping up the important dialogue between integrative and functional medicine clinicians, as well as her clear desire to educate the health care consumer in the process. Dr. David M. Brady (University of Bridgeport, Designs for Health, Inc., Diagnostic Solutions Labs, LLC, and DrDavidBrady.com)

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I’ve had the opportunity to review Dr. Kara Fitzgerald’s blogs. She is a well-recognized leader of functional, integrative medicine. Her blogs effervesce with her enthusiasm for her subject matter and convey her genuine warmth and compassion for her patients. She writes in an engaging style while conveying significant and meaningful information about the varied topics she has covered. They are simply fun to read and easy to learn from her wealth of experience.

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Quercetin for COVID19?

Author: Kara Fitzgerald, ND

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