High-dose biotin appears to be ineffective and potentially harmful in the treatment of progressive multiple sclerosis (MS), contradicting an earlier study.
A randomized trial from The Lancet of over 600 participants with MS found those who took 100 mg of biotin three times per day (10,000 times higher than the RDA) or placebo failed to improve MS disability. Biotin was recently recommended at this dose for MS based on a previous study, but this new study assessing safety and efficacy found the opposite. In addition, high dose biotin can interfere with laboratory results, particularly thyroid tests. The authors also found nearly 85% of participants in the biotin and placebo groups had adverse events – most commonly MS relapse.
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