Slowing Down Fast Food: The Metabolic Gap GLP-1s Can’t Reach & the Mechanism That Finally Closes It

The modern food environment makes post-meal metabolic stress harder than ever to manage, driving prediabetes, insulin resistance, and cardiometabolic disease. While lifestyle changes and GLP-1s help, patients need a sustainable option that fits their lives.

SiPore® targets this window locally in the GI tract. Using a patented mesoporous silica, it physically entraps digestive enzymes to slow carb and fat absorption—buffering metabolic stress at the meal itself.

Dr. Kara Fitzgerald, Dr. Sanjay Bhojraj, and Dr. Eric Johnston gathered to explore the clinical data and practical protocols for this innovative technology.

Key Takeaways:

• How post-meal glycemic and lipemic spikes drive progressive metabolic dysfunction.
• The gut-local mechanism behind SiPore® enzyme entrapment.
• SHINE trial outcomes: HbA1c, visceral fat, LDL-C, and lean mass preservation.
• Clinical integration: Patient selection, dosing, and protocols for prediabetes, weight management, and GLP-1 transitions.

In this session, they covered how to use SiPore Capsules & Liquid to target post-meal metabolic stress with a flexible, meal-level approach that expands your clinical toolbox.

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Sanjay Bhojraj, MD, FACC is an interventional cardiologist and Fellow of the American Academy of Anti-Aging Medicine (A4M) specializing in cardiometabolic health, longevity medicine, and precision cardiovascular prevention. With more than two decades of experience in advanced cardiovascular care, he combines conventional cardiology with root-cause and lifestyle medicine to help patients address the metabolic drivers of heart disease.

Dr. Bhojraj is the founder of the Laguna Institute of Functional Medicine, where he leads group-based cardiometabolic optimization programs and a concierge integrative cardiology and longevity practice. His programs focus on reversing metabolic dysfunction, improving energy and resilience, and reducing cardiovascular risk through targeted nutrition, sleep optimization, stress regulation, strength training, and advanced diagnostic testing.

He also works with patients using GLP-1 medications to develop safe metabolic transition strategies that support sustainable weight management while preserving metabolic health.

Through his clinical work, teaching, and digital health programs, Dr. Bhojraj is helping shape a new model of cardiovascular care—one that moves beyond reactive treatment toward proactive metabolic optimization and long-term healthspan.

Eric Johnston, Ph.D. is CTO and COO with deep expertise in synthetic mesoporous silica and life-science innovation. Trained as an organic chemist, he earned his Ph.D. from Stockholm University and has over 10 years of academic research experience, including work at Memorial Sloan Kettering Cancer Center in New York.

Eric has led the research, scale-up and operationalization of advanced material technologies, translating fundamental chemistry into regulated commercial applications. He combines scientific depth with operational execution, having built R&D organizations, secured multi-million SEK research grants, supervised doctoral and postdoctoral teams, and developed operating models for international life-science businesses. He has authored 34 peer-reviewed publications and 2 book chapters.