We think this might be controversial – let us know your thoughts!
As a functional medicine clinician, our daily work often revolves around a simple yet profound philosophy: the body has an innate ability to heal if we remove the obstacles and provide the right inputs. For decades, the “right inputs” have often been synonymous with “back to basics,” including whole, unprocessed foods and organic farming. The image this conjures is of going back to our traditional agricultural roots. We have long viewed “engineered food” as the problem, the very source of the ultra-processed, hyper-palatable “food-like substances” that drive the chronic disease epidemic we see today.
Now a new report, “Engineering Food Systems to Enable Precision Nutrition,” recently released by the Engineering Research Visioning Alliance (ERVA) and supported by the U.S. National Science Foundation, demands a reconsideration of the boundaries of our field. Its central argument is provocative: while nutrition problems manifest biologically, they cannot be solved through biological research alone. The translation of personalized, root-cause care into scalable, population-level health is currently constrained not by our lack of biological discovery, but by our lack of engineering capability.
What Are ERVA Reports Used For?
These reports are used to identify emerging engineering research priorities, guide public and private funding decisions, and align US strategic competitiveness in critical areas to improve the human condition.
In this EVRA report, the authors argue that their vision is one of using modern engineering and food “processing” to bring us closer to whole, nutrient-rich foods that are safe, affordable, and accessible at scale. It highlights the need to close the glaring gaps in our knowledge of unmapped food-derived metabolites (the “dark matter” of nutrition), unreliable dietary assessments, limited biomarker availability, insufficient understanding of individual variability, and absence of real-time systems that can accurately link dietary intake to biological response. Yet it also envisions engineered nutrient inputs and food stabilization, and the level of technology integration is dizzying. We’d love to hear what you think. Is this utopian or dystopian? After all… this is the framework that will guide nutrition research and innovation for the next several years.
A summary of the report follows below.
The ERVA Vision: Food-as-Medicine at Scale
The report envisions a transformation of the food system into a “responsive and measurable nutrition ecosystem”. The shift toward Precision Nutrition, in its true form (i.e., not just genomics) sounds great on paper. It’s defined as a dynamic approach to nutritional recommendations based on an individual’s unique variables: genetics, microbiome, metabolic profile, health status, and environment. In the future described by ERVA, the practice of personalized, root-cause medicine changes from a boutique service for those who can afford it into a scalable, engineered reality for everyone. But does it also take us somewhere more dystopian?
The report’s vision is premised on these 9 areas of nutrition research priorities, organized into 3 goals:
Goal 1: Food-as-Medicine Approaches to Disease Prevention
1. Optimize Nutrient Bioavailability and Stability through Processing Innovation. This priority seeks to shift food processing away from systems optimized primarily for yield and shelf-life toward nutrient-centric systems designed to preserve biological function. Engineering research will focus on developing high-throughput analytical tools and AI-enabled process controls that can dynamically protect the integrity of sensitive nutrients throughout the manufacturing cycle. By prioritizing minimally destructive processing methods, the goal is to ensure that essential compounds remain bioavailable and stable from the point of harvest to the point of consumption.
2. Engineer Delivery Systems that Cross Biological Barriers. To ensure that bioactive compounds exert predictable physiological effects, they must survive the harsh environment of the digestive tract. This research focuses on creating advanced delivery systems, such as programmable encapsulation technologies and tunable nano-carriers, that can control the timing and location of nutrient release. By utilizing structured food matrices and microbiome-targeted formulations, these systems aim to enhance bioaccessibility and bioavailability, moving beyond traditional additive-driven food formulations.
3. Develop Food-as-Medicine Platforms with Clinical-Grade Precision. Establishing food-based prevention strategies requires engineering systems that deliver reproducible and verifiable nutritional function. This priority envisions the use of precision fermentation and “biofactory crops” to produce agricultural outputs with standardized concentrations of bioactive compounds. These platforms will be supported by digital twins that model individual variability in nutritional response and modular manufacturing systems to deliver clinical-grade consistency and safety at a population scale.
Goal 2: Technologies (Tools, Processes, and Production Systems)
4. Build AI-Enabled Food Environments. Future food environments will function as intelligent cyber-physical systems that integrate sensing, computation, and automation to support real-time nutritional decision-making. These environments, ranging from smart home kitchens to large-scale institutional facilities, will use multimodal sensors to interpret physiological and behavioral signals, such as microbiome indicators or metabolic responses. The goal is to provide contextual guidance and automated preparation systems that make health-supportive choices easier to enact and verify in daily life. Essentially solving the compliance challenge.
5. Advance Processing Platforms for Personalized and Distributed Production. Moving away from centralized, one-size-fits-all manufacturing, this priority advocates for modular and tunable processing platforms capable of producing nutrient-dense foods tailored to specific demographic groups. These systems will use real-time sensing to ensure nutrient stability and bioavailability. By enabling on-demand assembly and finishing close to the point of consumption, these platforms support resilient, regional food systems and reduce the need for long-distance centralized supply chains.
6. Engineer Smart Packaging and Shelf-Life Systems with Embedded Sensing. This research aims to transform packaging from a passive container into an active monitor of nutrient integrity. Future platforms will integrate intelligent sensors that detect biogenic amines or volatile compounds, signaling shifts in freshness or safety in real time. By using embedded optical or electrochemical sensors, these systems can track the degradation of vitamins and probiotics throughout storage and distribution, providing consumers with verified indicators of nutritional quality rather than relying on static expiration dates.
7. Develop Circular Economy Technologies to Valorize Waste into Nutrient Inputs. Agricultural and food processing by-products, such as peels and husks, often retain high concentrations of valuable bioactive compounds that are currently discarded. This priority focuses on engineering technologies to recover, verify, and repurpose these nutrients into functional ingredients. By creating scalable extraction and bio-conversion systems, the food industry can transform “waste” into a reliable supply of high-value nutrient inputs, strengthening supply-chain resilience while reducing environmental impact.
Goal 3: Nutrition Insecurity and Increasing Local Foods
8. Advance Robotics and Automation for Nutrient-Centric Production. Robotics and automation will be redefined to prioritize nutrient composition and quality rather than yield alone. Engineering research will develop soft robotic manipulators and machine-vision systems capable of identifying optimal harvest windows based on biochemical maturity and nutrient density. These “Internet-of-Food” nodes will connect field or greenhouse sensing with regional data platforms, allowing agricultural practices to be precisely managed to meet specific nutritional targets.
9. Engineer Resilient Logistics and Storage Systems to Preserve Nutrient Quality. To protect the nutritional value of food as it moves through the supply chain, this priority focuses on nutrient-sensitive logistics systems. These infrastructures will use real-time sensor data and digital twin simulations to dynamically manage storage environments, including temperature and atmospheric composition. By advancing energy-efficient cold-chain and ambient-stable storage technologies, these systems aim to significantly reduce nutrient loss and ensure reliable access to high-quality nutrition across both urban and rural communities.
Is There a Good Version of Engineered Food?
The reality is that our modern food environment is already “engineered” in some way. Whole Foods farm raised salmon, for example, has a predictable quantity of omega-3 fatty acids and low environmental toxins (read our blog on the topic). That’s one version of engineering and would fit into the vision of this report. But most other examples, of course, are the ultra-processed kind, where foods are optimized for palatability, shelf-life, and cost rather than nutrient density and food-as-medicine qualities. This report aims to eschew this kind of engineered food.
A Clinician’s View: Are We Ready?
One central question we must face is whether traditional agricultural practices can truly scale to meet the needs of a growing global population while delivering the precise, individualized interventions required to reverse chronic disease. Are we beyond the point where a simple return to the past is a viable solution? Maybe. Yet, the fully-engineered future also seems daunting.
The strategies of this report are aimed squarely at reconnecting food to health, which isn’t hard to agree with in principle. And, arguably, we’re moving, whether we like it or not, into the omics era and everything that comes with it. Yet, change doesn’t always feel comfortable. We also have to wonder whether we are losing the connection to our environment in a way that could be detrimental? What other harms could we create along the way? The dark matter of nutrition is still… pretty dark. It’s hard to imagine we will fully understand all the intricate interactions with DNA and the epigenetic environment (noting the recent, heartbreaking CRISPR-related death here, even as there have also been lives saved).
There’s a lot to unpack here. Yet the vision is already set. The research dollars set in motion. Should we be taking a seat at the table and helping direct this forward in the best way possible?
Have you registered for the free 2026 Functional Medicine IS Longevity Medicine: A Masterclass for Clinicians? As the pace of innovation continues to ramp up, we’ll collectively tussle with the hard questions and divergent viewpoints to understand what clinicians can feasibly implement today. It’s coming up–September 18-19.





