From Hot Flashes to Healthspan: The FxMed Guide to Hormones & Longevity

From Hot Flashes to Healthspan: The FxMed Guide to Hormones & Longevity

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Few guests bring the kind of insight and energy that Dr. Carrie Jones does. She’s a dear friend, a brilliant colleague, and truly deserves her title of Queen of Hormones. With more than twenty years in women’s health and endocrinology, she has helped shape how we think about hormone testing and education in functional medicine. In this conversation, we dive into women’s hormones across the lifespan, with an extra focus on perimenopause, and how it ties back to mitochondrial health. Carrie brings humor and clarity to even the most complex topics, dropping clinical pearls along the way. It’s a fascinating and genuinely hopeful discussion you won’t want to miss. ~DrKF

Why Bone Loss Accelerates With Aging: The Gut–Bone Connection

Why Bone Loss Accelerates With Aging: The Gut–Bone Connection

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I just had a really fascinating conversation with the scientists at Sōlaria biō—Mark Charbonneau and Alicia Ballok—about a line of research that genuinely made me stop and rethink how we approach bone health. We talked about their journey from isolating microbes living inside edible plants, to identifying synergistic microbial interactions, to building out the preclinical work and then taking it all the way into human clinical research. It’s a rare and thoughtful progression, and the science is compelling. Their first clinical focus has been bone loss, and the results they’ve seen so far are striking. In an early clinical study, they reported a substantial reduction in bone loss—up to 80% in certain groups—along with meaningful reductions in CTX, one of the key markers we use to assess bone turnover. They’re now recruiting for a follow-up study in postmenopausal women in collaboration with Harvard, and we’ll share details in the show notes for anyone who may be eligible. This is a rich, science-forward conversation, and I think you’ll find it as interesting as I did. ~DrKF

Urolithin A for mitochondria and immune health

Human Clinical Evidence Supporting High-Dose Urolithin A for Mitochondrial and Immune Function

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Age-related declines in muscle function, immune resilience, and cellular energy are closely linked to mitochondrial dysfunction, making mitochondrial-targeted interventions a key focus of aging research. In this context, recent placebo-controlled human trials show that a Urolithin A dose of 1000 mg produces broader and more pronounced effects on mitochondrial gene expression, muscle performance, and immune markers than lower doses.

Podcast guest headshots

Epstein Files: A Functional Medicine Response

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This isn’t the podcast I expected to release this month. Not even close. But, in the wake of the most recent release of Epstein-related documents, things took a turn. In the face of what is such a colossal abuse of power over young women, it’s easy to feel paralyzed. In fact, along with a deep sense of pain, it was one of the first feelings that I felt as this new wave of information washed over us.

Is Infrequent Serum Hormone Testing Failing Peri- & Menopause Care? A Real-Time, Case-Based Guide

Is Infrequent Serum Hormone Testing Failing Peri- & Menopause Care? A Real-Time, Case-Based Guide

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Dr. Carrie Jones (ND, FABNE, MPH, MSCP) and Rose MacKenzie (Clinical Manager at Mira) join Dr. Kara Fitzgerald for a practical, case-based exploration of real-time hormone testing in perimenopause and menopause care. Traditional hormone testing often captures a single snapshot, missing the dynamic fluctuations that define the menopause transition. In this clinician-focused webinar, we’ll show how longitudinal, at-home hormone data can sharpen diagnostics, guide HRT decisions, and improve treatment monitoring. Using real patient cases and cycle charts, this session will walk through how continuous hormone insights can change clinical decision-making in practice.

Why Aging Is Not a Fat Problem — A Muscle-Centric Approach to Longevity

Why Aging Is Not a Fat Problem — A Muscle-Centric Approach to Longevity

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This was an energizing and important conversation with Dr. Gabrielle Lyon. Her ability to connect muscle health with metabolic stability, aging, and even our current misunderstanding of obesity lit up something for me. The idea that intramuscular adipose tissue may be the real driver of metabolic dysfunction, and that skeletal muscle is our most underappreciated longevity organ, brings a clarity and direction I think our field really needs. And I’ll say personally, talking with her made me rethink my own training and protein patterns, especially as I reflected on how my body responds now compared to years ago. There’s something profoundly validating, and also motivating, about realizing that the levers we can pull — protein, resistance, intensity — still work, and may matter even more as we age. I think you’re going to feel that same spark listening to her. ~DrKF

Platelet-Derived Exosomes in Aesthetics: Data, Safety, and Real-World Use Cases

Platelet-Derived Exosomes in Aesthetics: Data, Safety, and Real-World Use Cases

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Exosomes are having a moment right now, but this is the first time I’ve felt like I was able to sit down and really unpack what matters, the science behind them, the variability in sources, and why not all exosome products are created equal. In our conversation, Alisa Lask, CEO of Rion Aesthetics, helped bring clarity to a field that’s quickly becoming noisy, and I found myself genuinely impressed by the rigor and precision behind the platelet-derived exosomes she describes. For those of us watching regenerative aesthetics evolve, this discussion offers a grounded, thoughtful look at what’s real, what’s emerging, and what clinicians should be paying attention to. I think you’ll find it as illuminating as I did.

The Oral Microbiome: The Hidden Biomarker Driving Aging, Fertility & Systemic Inflammation

The Oral Microbiome: The Hidden Biomarker Driving Aging, Fertility & Systemic Inflammation

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The oral microbiome belongs squarely in the functional medicine toolkit, and my conversation with Staci Whitman, DMD, IFMCP, makes that more clear than ever. As a board-certified pediatric dentist and co-founder of the Institute for Functional Dentistry, Staci is reshaping her field into one that aligns with systems biology and root-cause care. She lays out, with real clarity, how oral dysbiosis, airway restriction, sleep, hormones, nutrition, and even dental materials influence systemic inflammation and chronic disease. She also offers clear steps we can take as medical practitioners, including when to consider oral microbiome testing and how to use a straightforward five-question airway screener in patient visits. For clinicians focused on longevity and upstream drivers of disease, this conversation shows how much more powerful our care becomes when dentistry becomes part of the clinical partnership.

Targeting Immune Aging: New Findings from the MitoImmune Study on Urolithin A (Mitopure®)

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Can Mitopure®, and its active ingredient Urolithin A, support an aging immune system? As we recognize immune aging as a primary driver of age-related disease, this question has taken on new clinical importance. The newly published MitoImmune study in Nature Aging provides the first rigorous clinical evidence to address this question. Conducted by researchers from Timeline, the Buck Institute for Research on Aging, and the lab of Professor.