gene-expression

Epigenetic Reprogramming Restores Age-Related Vision Loss in Mice

Intriguing new research shows that it is possible to reverse age-related cellular dysfunction in vivo, specifically age-related vision loss. This suggests that modifying epigenetic expression is a powerful tool to counteract the damage of aging. The study published in Nature sought to reset the epigenome and DNA methylation patterns by expressing transcription factors, which help…

Episode 75: Aging as an Evolutionary Program with Dr. Josh Mitteldorf

Episode 75: Aging as an Evolutionary Program with Dr. Josh Mitteldorf

As FxMed docs, we’re committed to working with the body’s own capacity for health. Dr. Josh Mitteldorf offers a contrarian strategy, one which he says is grounded in a new breed of evolutionary medicine. He tells us that diseases of old age are qualitatively different from the diseases we get when we’re younger, different because in old age, our bodies are part of the problem, not part of the solution. Aging, says Josh, is the body deliberately destroying itself (for the sake of the population), via inflammation and apoptosis and autoimmune diseases. In this interview, Josh and I find common ground talking about hormesis. In Josh’s theory, the fact that the body lives longer when stressed (e.g. caloric restriction) is proof that the body isn’t trying its hardest to stay young when it’s not stressed.

Episode 62: Methionine Metabolism and Methylation with Dr. David Quig

Episode 62: Sponsored | Methionine Metabolism and Methylation with Dr. David Quig

Methylation and sulfuration are complex processes and assessing them in practice takes skill, knowledge, and consideration of multiple genes and other factors. Lucky for us, we have the incredible Dr. David Quig from Doctor’s Data on the podcast today, getting into the nitty-gritty about assessing methylation in clinical practice.

Methylation Adaptogens: Spotlight on Exercise

Methylation Adaptogens: Spotlight on Exercise

This article originally appeared on NDNR.com Up until now, we’ve been putting a heavy emphasis on supplementation with B vitamins, betaine, choline and other substrates and cofactors for methylation support. However, there are a number of other and perhaps unexpected ways in which we can balance methylation expression (both metabolically and genetically). This includes preventing…

Methylation Trail Mix

Methylation Trail Mix

We love pumpkin seeds and sunflower seeds for their rich minerals, B vitamins and essential fatty acids. They also make a delicious snack, especially in a methylation trail mix recipe like this one. Chocolate tip: Look for organic, dark chocolate (70%+ cacao) wherever you can. Check to make sure you’re comfortable with the ingredients! What…