Alpha ketoglutarate (AKG)

Notes from DrKF:

AKG is an essential cofactor for DNA demethylation via the TET family of enzymes. Thus, it’s really important in helping hypermethylated genes to be turned back on, as well as cleaning up the epigenome during embryogenesis. AKG is also a key player in the production of energy in our mitochondria. We can make AKG in the body pretty easily, but it seems to drop in quantity as we age. There is compelling preclinical research on AKG as an anti-aging molecule that supports muscle, burning fat, and boosting mitochondrial activity.

Dosage: 300–600 mg per day.

Klaire Labs Alpha-Ketoglutaric Acid 300 mg


Alpha-ketoglutaric acid (also known as alpha-ketoglutarate) is important for the proper metabolism of all essential amino acids and the transfer of cellular energy in the citric acid, or Krebs, cycle.* It is also essential for appropriate DNA demethylation.*