Notes from DrKF:

What happens if, like some of my patients, you absolutely cannot tolerate or take B12 and folate, you’re doing the full Intensive program, but you still need extra methyl donors? A somewhat circuitous approach (hence the “backdoor” name) to supporting DNA methylation is to take supplements of nutrients that otherwise require a lot of methyl donors for your body to make. When you do that, you’re taking any extra load off your methylation pathways, allowing your body to increase its methylation support in other important areas. Two supplements that help you do this are:

Choline | Creatine

Klean Athlete Klean Creatine

$28.70

Creatine is often used by athletes, but can also be a useful “backdoor” methylation support supplement, especially for those who don’t tolerate B vitamins well, and those with cognitive decline, muscle loss, fatigue, or extra energy requirements.*

Metagenics Creatine UP

$48.00

Creatine is often used by athletes, but can also be a useful “backdoor” methylation support supplement, especially for those who don’t tolerate B vitamins well, and those with cognitive decline, muscle loss, fatigue, or extra energy requirements.* This supplement also contains betaine, another highly useful DNA methylation-supportive compound.