Mapping the Placental Methylome: The Key to Early Autism Intervention with Dr. Janine LaSalle

Towards Predicting Autism in Utero with Dr. Janine LaSalle

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This pioneer scientist mapped the human placental methylome. That is, all of the DNA methylation marks on the placenta, and has associated changes with neurodevelopmental disorders. She’s also demonstrated the influence of toxins and insufficient folate. Of the many implications inherent in her work, very exciting to me is the fact that we are moving toward in utero diagnostics using mom’s blood (ie, a standard blood draw). My hope is one day we will identify issues and address them all before baby is born!

Cutting Edge Interventions For Patients with Adverse Food Reactions with Dr. Tom Fabian

Challenging Food Reactions? Addressing the Gut Microbiome and More with Dr. Thomas Fabian

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In this episode, we’re diving into the forefront of understanding adverse food reactions, a topic that’s experiencing a significant paradigm shift in both perception and treatment strategies. Our guest, Dr. Thomas Fabian, a leading expert on the role of the microbiome, will shed light on the underlying pathophysiology of these reactions. We’ll discuss specific gut microbes and microbial functions identified in recent studies, providing concrete examples of their involvement in various types of adverse food reactions.Join us as we navigate through the latest advancements in immune tolerance understanding, microbial variances in the gastrointestinal tract, and the profound influence of GI physiology on adverse food reactions.Stay tuned for an enlightening discussion that will undoubtedly shape the future of functional medicine practice. ~DrKF

Microbiome Reset: Building Childhood Resilience with Dr. Elisa Song

Smart, Actionable Strategies for Childhood Resilience, with Dr. Elisa Song

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I’m delighted to welcome back Dr. Elisa Song, a respected colleague and pioneer in pediatric functional medicine. Today, we’re delving into the critical intersection of the gut microbiome and pediatric health. In today’s landscape, families are confronted with daunting challenges. Between the 3000 chemicals hiding in ultra-processed foods, alarmingly high sugar content (sometimes as much as 14 teaspoons in a single drink!), and the pervasive presence of antibiotics in our food supply, it’s no surprise that we’re seeing negative changes in the microbiome, worsening metabolic health, increased allergies, autoimmune disease, and neurodevelopmental issues.

Urolithin A and GLP-1 Agonists: A winning combination with Dr. Anurag Singh

Mitigating Muscle Loss from GLP-1 Agonists, with Dr. Anurag Singh

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I am paying attention closely to research coming from the largely untapped world of postbiotic compounds and their essential role in human physiology. I have had the honor to talk quite a few times with Dr. Anurag Singh, and always the clinical (and preclinical) research that he and his team are up to looking at postbiotic wunderkind urolithin A (a compound produced by GI bacterial action on precursor compounds found in pomegranate) are thrilling, powerful and illustrate how wildly important these compounds are in human physiology

New Frontiers in Functional Medicine® Podcast

Tackling Alzheimer’s Disease Head On – the Inspiring Work of Dr. Heather Sandison

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Today, I am honored to connect with Dr. Heather Sandison, whose work in reversing Alzheimer’s is nothing short of groundbreaking. Her dedication challenges the status quo of dementia care, offering real hope and tangible solutions. We’ll explore the intricacies of Alzheimer’s disease, from its elusive diagnosis to the shortcomings of traditional pharmaceuticals. Together, we’ll navigate the realm of evidence-based interventions, from early detection to personalized treatments, all aimed at optimizing cognitive function and overall well-being. Join us for a conversation that promises to ignite new possibilities in our approach to dementia care.

Reducing Senescent Cell Accumulation for Enhanced Longevity with Dr. Greg Kelly

Targeting Senescent Cells? Dose and Timing Matters – with Dr. Greg Kelly

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I’m thrilled to welcome you to a truly fascinating discussion on the cutting edge of longevity medicine. In this episode, I sit down with the brilliant Dr. Greg Kelly to explore the complex world of cellular senescence and its profound implications for our aging process. We delve into the challenges of identifying these aging cells and the exciting research that’s paving the way for more accurate biomarkers. I’m particularly excited to share with you Dr. Kelly’s insights on how simple lifestyle changes, such as incorporating regular exercise and mindful caloric intake, can significantly reduce the accumulation of senescent cells. We also discuss some groundbreaking interventions, including the use of senolytic agents like quercetin, dasatinib, and piper longumine, and how they’re revolutionizing our approach to longevity.

Metabolic Engineering: The Science Behind Staying in the Zone with Dr. Barry Sears

Dr. Barry Sears (of Zone Diet Fame) on Lifetime Metabolic Health and Sourcing Omega-3s

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In today’s episode, I’m thrilled to speak with Dr. Barry Sears, the creator of the Zone Diet, an approach that has not only topped bestseller lists multiple times but has also profoundly impacted nutritional practices really across the world. We dive into his transition from cancer research to nutritional science, focusing on how diet regulates the key areas of inflammation and hormonal balance. Dr. Sears shares insights from his groundbreaking work, exploring the balance of macronutrients and the pivotal role of omega-3 fatty acids and polyphenols. His contributions have revolutionized how we understand diet’s impact on health, offering valuable strategies for managing chronic diseases and optimizing wellness globally. You’ll find many clinical pearls in this conversation. Join us as I uncover the science and stories behind this influential dietary philosophy with this legend of nutrition and wellness. ~DrKF

Unraveling PCOS and Fertility: Debunking Common Misconceptions with Dr. Tara Harding

Unraveling PCOS and Fertility: Debunking Common Misconceptions with Dr. Tara Harding

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Fellow clinicians, gear up for an enlightening dive with Dr. Tara Harding, a vanguard in the realm of women’s health and fertility. Renowned for her exceptional work as a family nurse practitioner and fertility coach, Dr. Harding brings a wealth of knowledge from her battle against infertility and medical gaslighting, all while breaking barriers and fostering a supportive community for those navigating the complex journey of infertility. This conversation not only highlights innovative diagnostic tools like Mira but also delves into the nuances of managing conditions like PCOS and endometriosis. Dr. Harding’s personal and professional journey is a beacon of hope and empowerment, underscoring the significance of comprehensive care in women’s health. Prepare to be inspired by her dedication to revolutionizing fertility care and advocating for patient empowerment.

AI, Digital Twins, and the Future of Personalized Medicine Interventions with Dr. Nathan Price

AI, Digital Twins, and the Future of Personalized Medicine Interventions with Dr. Nathan Price

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I’m beyond thrilled to share this mind-blowing conversation with Dr. Nathan Price, Chief Scientific Officer of Thorne HealthTech and author of The Age of Scientific Wellness. Imagine harnessing AI to predict outcomes of our functional interventions (diet, supplements, lifestyle) by implementing a “digital twin” model that is populated with all of your patient’s bio data. Being able to test the response of our treatments (and importantly, the synergistic response of multimodal interventions! It’s heady stuff, but amazingly, it is where we are headed today. Dr. Price illuminates the incredible potential this technology brings for personalized evidence-based medicine in nutrition, tailoring interventions based on microbial markers, and addressing lifestyle changes for Alzheimer’s prevention. The podcast is a captivating exploration of cutting-edge concepts and provides a glimpse into the exciting future of healthcare. I was wowed by my convo with Nathan and can’t wait to start kicking the tires on this baby. I know you’ll feel the same.

Decoding Aging: The Science Of Cellular Rejuvenation With Dr. Vittorio Sebastiano

Decoding Aging: The Science Of Cellular Rejuvenation With Dr. Vittorio Sebastiano

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Why? Dr. Sebastiano has demonstrated in his laboratory that epigenetics, and primarily DNA methylation, is hierarchically dominant over all other hallmarks of aging. This is extraordinary. He has demonstrated in his laboratory (using Yamanaka factors) that when DNA methylation patterns are made more youthful, the other downstream hallmarks of aging also become more youthful.