The Bile Acid Imbalance Accelerating Aging: How to Detect & Fix It

The Bile Acid Imbalance Accelerating Aging: How to Detect & Fix It

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Have you ever struggled to understand why some patients just don’t respond as expected, even when you’re following all the usual gut protocols? In this episode, I sat down with Dr. Tom Fabian, who breaks down the latest insights from StoolOMX and GI-MAP testing and shows us how to put them into practice for our most complex cases. We dive into how identifying specific types of inflammation, bile acid patterns, and microbial imbalances can guide more precise interventions, whether it’s introducing fiber, addressing biofilms, or supporting secondary bile acid production. Dr. Fabian makes the science practical, helping us see not just what’s happening in the gut, but what to do about it in real-world clinical settings. ~DrKF

Why Functional Medicine Is the Future of Longevity

Why Functional Medicine Is the Future of Longevity

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This is the longevity conversation functional medicine providers need to hear. What struck me in each of these conversations is how deeply functional medicine already holds the answers we’re chasing in longevity science. We don’t need to reach for extremes. The tools we use every day—our frameworks, our lens, our root-cause approach—are longevity medicine. If you’re a clinician who’s felt unsure about where you fit in this rapidly growing space, I want this episode to remind you: you’re already in it. You’ll hear how leaders in our field are using the functional medicine matrix to slow cognitive decline, decode inflammatory pathways, and reframe aging itself as a process we can impact—intelligently and safely.

Why Centenarians Are Defying Science: Secrets to Living 100+

Why Centenarians Are Defying Science: Secrets to Living 100+

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This conversation with Dr. Nir Barzilai is one of the most thought-provoking we’ve had on New Frontiers. His decades of research on centenarians, biological age, and the hallmarks of aging have shaped how we think about longevity—and what’s possible when we start targeting aging itself, not just individual diseases. We get into the science behind why some people live 20–30 years longer and healthier, and what it means to measure the biological age of individual organs. But we also hit a few sparks—especially when it comes to nutraceuticals and the role of metformin in prevention. I don’t agree with everything you’ll hear, and I followed up with Dr. Barzilai afterward to unpack some of the more provocative claims. We may just need a second round for this one… stay tuned.

The Science-Backed Bitter Compound That Mimics GLP-1 (No Injections Needed!)

The Science-Backed Bitter Compound That Mimics GLP-1 (No Injections Needed!)

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I’ve been watching the science behind Calocurb evolve over the last year, and I have to say—this is one of the most exciting clinical tools I’ve seen emerge in the metabolic space in quite some time. A hops-derived compound that stimulates endogenous GLP-1, CCK, and PYY—without a prescription or injection? That’s a big deal, especially for patients struggling with appetite regulation, weight plateaus, or the aftermath of GLP-1 discontinuation.

Dead Mitochondria Might Be Fueling Cardiovascular Aging — Here’s The Fix

Dysfunctional Mitochondria Are Fueling Cardiovascular Aging — Here’s The Fix

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This is a really exciting conversation with Dr. Davide D’Amico from Timeline, where we’re taking a closer look at Urolithin A and heart health. It should come as no surprise that this mitochondrial wonderkin of a nutrient is showing promise here—especially when you consider that 40% of the heart’s weight is mitochondria. That’s an extraordinary factoid, and one that really shifts how we think about aging in the cardiovascular system.

Why Human-Centered AI Is the Future of Medicine & Mental Wellness

Why Human-Centered AI Is the Future of Medicine & Mental Wellness

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This episode is a little different from what we usually cover on New Frontiers, but it’s one I couldn’t wait to bring to you. I’ve been thinking a lot about how we—as clinicians—are supposed to keep up in this era of high-throughput technology. We’re swimming in data: labs, multi-omics, diet logs… and an ever-growing stream from wearables. There’s just so much coming at us, and too often, we’re awash in a sea of information without adequate interpretive power.

Legal Pitfalls That Could Destroy Your Practice & How to Avoid Them

Legal Pitfalls That Could Destroy Your Practice & How to Avoid Them

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In many ways, the legal side of functional medicine can feel like the Wild West—uncertain, unregulated, and full of risks. The reality is, we all want to have our practices legally buttoned up, but navigating the legal landscape can feel overwhelming—and expensive. What Scott Rattigan, creator of Functional Lawyer, shares in this episode is a real game-changer. He not only breaks down the complexities of the legal side of things but also offers real solutions for us—solutions that can make sure we’re covered without the stress and uncertainty that often comes with it. Whether you’re just starting out or growing your established practice, you’re going to get actionable insights on how to avoid common legal pitfalls, protect your practice, and actually move forward with confidence. It’s a topic that’s been an unmet need for so long, and I’m so excited to bring this to you. ~DrKF

Why You’re Aging Faster Than You Think & How to Slow It

Why You’re Aging Faster Than You Think & How to Slow It

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I’ve been looking forward to sharing this conversation with you because it’s one I’m truly passionate about. Today, we’re diving into the DunedinPACE epigenetic clock with one of its creators, the brilliant Dan Belsky. It’s a tool I use regularly with my patients, and one that’s transforming how we approach aging and interventions. While this show is a bit more technical than usual, the science is fascinating, and the real-world applications are incredibly valuable. This isn’t just about theory—it’s about practical insights that can change how we measure aging and track the effectiveness of the treatments we offer. Stick with us, and you’ll walk away with actionable knowledge that can make a difference in your practice. ~DrKF

Can We Regrow Joints and Reverse Inflammaging? New Research Suggests YES

What New Research Says About Cartilage Regeneration and Joint Longevity

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Osteoarthritis affects millions—chronic pain, limited mobility, and a dramatically reduced quality of life. But what if the answer isn’t just about treating the joint, but the inflammation driving the damage? In today’s episode, Kiran Krishnan, a leading microbiologist and advisor to Calroy Health Sciences, unveils a groundbreaking approach to joint health. He explains how chronic low-grade inflammation fuels osteoarthritis and accelerates joint degeneration. Even more exciting? Cartigenix, a revolutionary product combining unique extracts from celery seed and Boswellia, is showing real potential to regenerate cartilage, reduce pain, and improve mobility. Kiran also dives into the fascinating link between osteoarthritis and cardiovascular disease, why supporting liver health plays a crucial role in optimizing joint repair and how preventative strategies like Cartigenix can protect your joints before they start to decline. This episode could change everything you know about managing inflammation and joint health—don’t miss it!