Notes from DrKF:
Creatine phosphate is a molecule used in the body to rapidly recycle ATP, the body’s main source of energy, in high-energy tissue, including skeletal muscles, heart muscle, and the brain. You synthesize and recycle creatine in the kidneys via a process that requires a lot of methyl donors (just think about all of the skeletal muscle you have—even if you’re not a bodybuilder, added up together, skeletal muscles make up the largest organ in your body). For this reason, I sometimes prescribe creatine to spare those many methyl donors for use in other pathways, such as DNA methylation.
Folks who might benefit from creatine are those who don’t tolerate B vitamins but need them, those with cognitive decline, muscle loss (sarcopenia), fatigue, or individuals who require extra energy support. Athletes can also benefit from extra creatine.
Dosage: I generally start daily dosing at 1 gram and may increase up to 5 grams.
Creatine is often used by athletes, but can also be a useful “backdoor” methylation support supplement, especially for those who don’t tolerate B vitamins well, and those with cognitive decline, muscle loss, fatigue, or extra energy requirements.*
Creatine is often used by athletes, but can also be a useful “backdoor” methylation support supplement, especially for those who don’t tolerate B vitamins well, and those with cognitive decline, muscle loss, fatigue, or extra energy requirements.* This supplement also contains betaine, another highly useful DNA methylation-supportive compound.
