Omega 3 & SPMs
Notes from DrKF:
It’s rare to consume enough of the longer-chain omega 3s, which are DHA and EPA. DHA in particular is suggested to support the methylation cycle (where we synthesize the universal methyl donor SAMe that works with DNA methylation). We’re also particularly bullish on specialized pro-resolving lipid mediators (SPMs)—compounds our bodies make from omega 3s—that are important for many reasons, including their essential role in turning off inflammation and in brain health, pain relief, and more. While research is still forthcoming, given the number of SPMs we make in our bodies (including in our brains) and their wide role in health, I expect we’ll see them as beneficial influencers on the epigenome, particularly as it pertains to inflammation.
Dosage: We routinely prescribe omega-3 supplements, around 2000 mg per day for healthy adults of a blend of EPA and DHA. For patients dealing with inflammation, we go up to 5000 mg per day. SPMs are available in doses ranging from 500-1000mg. We recommend adding SPMs at 1000mg per day when inflammation of any form is an issue.