Methylation Diet and Lifestyle

“Kara has written and produced the most comprehensive, organized, and yes, dare I say WISE, guide to methylation that I have seen. I am so impressed with this e-book. As I was reading it, I kept thinking, ‘Here we have, in Kara, one of the next leaders of Functional Medicine’. Read this ebook, study it, and apply it. Your patients and your practice will be changed for the better.”

Robert J. Hedaya, MD, DLFAPA | Clinical Professor of Psychiatry, Georgetown University Hospital | Founder, the National Center for Whole Psychiatry | Faculty, The Institute for Functional Medicine

eBook: The Methylation Diet and Lifestyle – Buy Now!

The “dance of methylation” extends far beyond supplementing with B12 and methylated folate. Indeed, long term outcome studies using this approach are lacking, and research suggests caution is advised with regard to imbalanced hypermethylation. However, much can be done to safely support methylation balance.

Sparing “methyl donor drain” through appropriate lifestyle interventions, including reducing total body inflammation, augmenting the microbiome and promoting exercise, stress reduction and sufficient sleep, along with a careful dietary prescription that supports methyl donor reserve is a safe, nuanced approach which allows the complex, homeodynamic process of methylation to take place.

In The Methylation Diet and Lifestyle, you will find:

  • 140 Pages with over 150 References
  • An explanation of the functions of methylation in the body, as well as its biochemistry and nutrient requirements
  • A description of the clinical problems surrounding methylation, including MTHFR and other gene SNPs and nutrient deficits
  • A comprehensive discussion of the pros and cons of supplemental methylation nutrients (including folic acid vs 5mTHF), as well as a review of the literature that strongly suggests we should proceed with caution in pushing enzymatic reaction rates, to avoid hypermethylation states
  • How to approach methylation assessment in a more comprehensive manner, including genetics, metabolic markers, nutrient status and more
  • What foods provide safe forms of methylation-related nutrients, and dietary patterns that support healthy methylation
  • How lifestyle factors such as stress and exercise, and other physiological conditions such as inflammation, oxidative stress, toxin exposure, microbiome imbalance and malabsorption can impact methylation status and what to advise
  • Two 7-day menu plans (one gluten- and dairy-free, one Paleo) with over 40 recipes, and detailed nutrient analysis so you know how much of each methylation nutrient is provided
  • Practitioner checklists for assessment and intervention options

Get the FREE Methylation Diet and Lifestyle eBook Sampler

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Want to learn more? Get access to the training webinars given by Dr. Kara Fitzgerald and Romilly Hodges to the team at the Cleveland Clinic Center for Functional Medicine on the Methylation Diet and Lifestyle.

Dr. Kara Fitzgerald
Dr. Kara Fitzgerald

Dr. Kara Fitzgerald

Dr. Fitzgerald is a Certified Functional Medicine Clinician, with a focus on chronic disease. She is well-known for her background in laboratory science and her role on the faculty of the Institute for Functional Medicine. She treats a wide variety of conditions, including, but not limited to those listed below.

Romilly Hodges, MS CNS
Romilly Hodges, MS

Romilly Hodges, MS

Romilly Hodges, MS CNS, holds a Master’s Degree in Functional Nutrition from the University of Bridgeport, CT, and is a Certified Nutrition Specialist (CNS). She is passionate about the power of food to nourish and heal the body.

Our Functional Medicine Services


A chronic condition including attention difficulty, hyperactivity, and impulsiveness.


Conditions in which the immune system reacts abnormally to a foreign substance.


Also colloquially known as male menopause — is said to be the result of a gradual drop in testosterone, which is an androgen.

Apthous Stomatitis

A small, shallow sore inside the mouth or at the base of the gums.

Atopic Dermatitis

Atopic Dermatitis is an itchy inflammation of the skin.

Autoimmune Disease

A disease in which the body’s immune system attacks healthy cells.

Burning Mouth Syndrome

(BMS) is an idiopathic condition characterized by a continuous burning sensation of the mucosa of the mouth

Cancer Support and Prevention

An estimated two-thirds of all cancers are preventable. Information and education are key to cancer prevention

Cardiac Disease Prevention & Risk Reduction

A disease in which abnormal cells divide uncontrollably and destroy body tissue.

Chronic Constipation/Diarrhea

A common condition that is characterized by difficult, infrequent, or perceived incomplete evacuation of bowel movements.

Chronic Fatigue Syndrome

A disease characterized by profound fatigue, sleep abnormalities, pain, & other symptoms that are made worse by exertion.


A condition in which there is difficulty in emptying the bowels, usually associated with hardened feces.


A mood disorder causing a persistent feeling of sadness and loss of interest.


A group of diseases that result in too much sugar in the blood, or high blood glucose.


A disorder in which tissue that normally lines the uterus grows outside the uterus.

Environmental Toxicity

Understanding of the harmful effects of various chemical, biological and physical agents on living organisms.


Widespread muscle pain and tenderness. Fibromyalgia affects an estimated 5.8 million Americans.

Food Allergies/ Intolerances

An unpleasant or dangerous immune system reaction after a certain food is eaten.

Gastro Esophageal Reflux Disease

A digestive disease in which stomach acid or bile irritates the food pipe lining.

Gastrointestinal Disorders

Irritable Bowel Syndrome (IBS) A number of factors can trigger IBS including certain foods, medicines, and emotional stress.

Gluten Sensitivity

An immune reaction to eating gluten, a protein found in wheat, barley, and rye.


A condition in which the force of the blood against the artery walls is too high.


A condition in which the thyroid gland doesn’t produce enough thyroid hormone.

Infectious Diseases

Caused by pathogenic microorganisms, such as bacteria, viruses, parasites or fungi; the diseases can be spread.

Inflammatory Bowel Disease

Ongoing inflammation of all or part of the digestive tract.


Persistent problems falling or staying asleep or both.

Intestinal Permeability (Leaky Gut)

Intestinal permeability is the phenomenon of the gut wall in the gastrointestinal tract exhibiting permeability.

Irritable Bowel Syndrome

An intestinal disorder causing pain in the belly, gas, diarrhea, and constipation.

Lead Toxicity

Also called plumbism is a buildup of lead in the body, usually over months or years.


Common symptoms include hot flashes and vaginal dryness and possibly sleep disturbances. The combination of these symptoms can cause anxiety or depression.

Mercury Toxicity

Inorganic mercury toxicity often causes skin rashes and inflammation (dermatitis)

Metabolic Syndrome

A cluster of conditions that increases the risk of heart disease, stroke, and diabetes.


A headache of varying intensity, often accompanied by nausea and sensitivity to light and sound.

Mitochondrial Dysfunction

A group of disorders caused by dysfunctional mitochondria, the organelles that generate energy for the cell.

Mood Disorders

a psychological disorder characterized by the elevation or lowering of a person’s mood, such as depression or bipolar disorder.

Multiple Sclerosis

A disease in which the immune system eats away at the protective covering of nerves.

Muscle Spasms

A sudden and involuntary contraction of one or more of your muscles.

Neurodevelopmental Degenerative Disorders

A group of disorders in which the development of the central nervous system is disturbed


A disorder involving excessive body fat that increases the risk of health problems.


Reduced bone mass of lesser severity than osteoporosis.


A condition in which bones become weak and brittle.

Polycystic Ovary Syndrome

A hormonal disorder causing enlarged ovaries with small cysts on the outer edges.

Premenstrual Syndrome

A group of symptoms that occur in women, typically between ovulation and a period.

Prostate Health

There is a lot you can do to keep your prostate healthy as you age—and stay ahead of the game

Psoriatic Arthritis

A form of arthritis that affects some people who have the skin condition psoriasis.

Rheumatoid Arthritis

A chronic inflammatory disorder affecting many joints, including those in the hands and feet.


A condition in which the cavities around the nasal passages become inflamed.

Stress Related Anxiety

Stress can be triggered by an event that makes you feel frustrated or nervous.

Stress Related Fatigue

Emotional, or physical stress drains the adrenal glands and causes many common symptoms.

Thyroid Disease

Any dysfunction of the butterfly-shaped gland at the base of the neck (thyroid).

Viral Syndromes

A term caregivers use for general symptoms of a viral infection that has no clear cause.

Vitamin Deficiencies

Vitamin Deficiencies is a deficiency of one or more of the bodies essential vitamins.

Yeast Infections

A fungal infection typically on the skin or mucous membranes caused by candida.