Methylation – What’s All the Fuss?
If you or anyone you know has a history of heart disease, depression, Alzheimer’s disease, ADHD, diabetes, insomnia or autism, these are just some of the conditions that have been linked to faulty methylation.
If you or anyone you know has a history of heart disease, depression, Alzheimer’s disease, ADHD, diabetes, insomnia or autism, these are just some of the conditions that have been linked to faulty methylation.
Up until now, having a gene SNP in methylation enzymes (such as MTHFR), elevated homocysteine, or before and during pregnancy, has typically prompted the use of supplemental methylation cofactors such as B12, folate, B6 and betaine. Often at higher level doses. Yes, it’s right to correct or avoid too little methylation activity in the body,…
New Frontiers in Functional Medicine® Podcast Sponsors Dr. Kara Fitzgerald is eternally grateful to our sponsors who, by blogging, podcasting and advertising with us, enable me and my team to devote energy and time to writing and publication. Exclusive Offer for New Frontiers Listeners Book a practitioner call and receive a complimentary bottle of beta-glucan…
As functional medicine practitioners, we know that nutrition and lifestyle are among the most powerful levers for preventing and reversing all chronic disease, from cardiovascular disease and hypertension to cancer and type 2 diabetes. Yet we also see firsthand how challenging it can be for patients to translate recommendations into sustained daily practice. Deeply ingrained habits don’t shift overnight. In fact, a meta-analysis of 20 studies involving more than 2,600 participants found that health-related habits typically take 2–5 months to form, which is far longer than the popular “21-day” myth suggests.
In this practitioner spotlight, Dr. Darisa Espinal, naturopathic physician at Dr. Kara Fitzgerald’s New Frontiers Functional Medicine Clinic, shares her journey into functional medicine, the types of patients she supports, and how she integrates longevity medicine and root-cause care to help patients achieve optimal health and vitality. Dr. Espinal, can you share your path to becoming a functional medicine doctor and how your training shaped your approach to patient care?
These energy bites are a seed extravaganza! Infused with anti-inflammatory turmeric and fragrant lemon zest, they offer a punchy flavor while delivering healthy fats, fiber, and a whole host of longevity-boosting epinutrients (see below). Naturally sweetened and rich in antioxidants, they make a refreshing, feel-good snack for any time of day.
This is the longevity conversation functional medicine providers need to hear. What struck me in each of these conversations is how deeply functional medicine already holds the answers we’re chasing in longevity science. We don’t need to reach for extremes. The tools we use every day—our frameworks, our lens, our root-cause approach—are longevity medicine. If you’re a clinician who’s felt unsure about where you fit in this rapidly growing space, I want this episode to remind you: you’re already in it. You’ll hear how leaders in our field are using the functional medicine matrix to slow cognitive decline, decode inflammatory pathways, and reframe aging itself as a process we can impact—intelligently and safely.
I’ve been watching the science behind Calocurb evolve over the last year, and I have to say—this is one of the most exciting clinical tools I’ve seen emerge in the metabolic space in quite some time. A hops-derived compound that stimulates endogenous GLP-1, CCK, and PYY—without a prescription or injection? That’s a big deal, especially for patients struggling with appetite regulation, weight plateaus, or the aftermath of GLP-1 discontinuation.
Before we dive in—I just want to say thank you. Ten years of New Frontiers wouldn’t have been possible without your support, your curiosity, and your commitment to moving this field forward. I’m so excited to share this conversation with Romilly. ~ DrKF
Recent peer-reviewed research on the Younger You program reveals that: The Younger You program can increase your intake of beneficial, phytonutrient-dense foods more than other diet programs studied for their beneficial effects on bio age (like the Mediterranean diet).
Dr. Fitzgerald is an internationally-recognized expert clinician, as well as nationally-bestselling author, who is actively engaged in clinical research on epigenetics and longevity using a diet and lifestyle intervention developed in her research and practice.
She has published two clinical studies on the potential bioage-reversing effects of an 8-week DNA methylation-supportive diet and lifestyle in middle-aged men and women in the journal Aging. She continues to lead the conversation around interventions for healthy aging and their extensive potential in improving individual and population level disease burdens, while also providing evidence-based and practical advice that cuts through the hype.
Dr. Fitzgerald is on faculty at the Institute for Functional Medicine (IFM), is an IFM Certified Practitioner, and lectures globally on functional medicine, longevity, and epigenetics to practitioners and consumers.
She maintains an award-nominated podcast series ranked in the top 1% of global podcasts by Listen Score, New Frontiers in Functional Medicine, and an active blog and Clinic Immersion webinar series through her website, www.drkarafitzgerald.com.
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