Mapping the Placental Methylome: The Key to Early Autism Intervention with Dr. Janine LaSalle

Towards Predicting Autism in Utero with Dr. Janine LaSalle

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This pioneer scientist mapped the human placental methylome. That is, all of the DNA methylation marks on the placenta, and has associated changes with neurodevelopmental disorders. She’s also demonstrated the influence of toxins and insufficient folate. Of the many implications inherent in her work, very exciting to me is the fact that we are moving toward in utero diagnostics using mom’s blood (ie, a standard blood draw). My hope is one day we will identify issues and address them all before baby is born!

Microbiome Reset: Building Childhood Resilience with Dr. Elisa Song

Smart, Actionable Strategies for Childhood Resilience, with Dr. Elisa Song

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I’m delighted to welcome back Dr. Elisa Song, a respected colleague and pioneer in pediatric functional medicine. Today, we’re delving into the critical intersection of the gut microbiome and pediatric health. In today’s landscape, families are confronted with daunting challenges. Between the 3000 chemicals hiding in ultra-processed foods, alarmingly high sugar content (sometimes as much as 14 teaspoons in a single drink!), and the pervasive presence of antibiotics in our food supply, it’s no surprise that we’re seeing negative changes in the microbiome, worsening metabolic health, increased allergies, autoimmune disease, and neurodevelopmental issues.

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Past, Present, and Future of “Biological Aging” with Dr. Fitzgerald

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Team DrKF sat down with Dr. Fitzgerald to pose some questions about the “state of the state” of longevity research, current controversies and future directions, and where she sees her work fitting into it. When it comes to defining and using measures of biological age, where does the science currently stand? To understand where we currently stand, and why changes are afoot, we have to first consider where we’ve come from. When Steve Horvath at UCLA released the first epigenetic biological age clock in 2013 it marked the entry of longevity medicine into the mainstream (referred to as biogerontology in science, anti-aging medicine in some clinical circles).

Reducing Senescent Cell Accumulation for Enhanced Longevity with Dr. Greg Kelly

Targeting Senescent Cells? Dose and Timing Matters – with Dr. Greg Kelly

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I’m thrilled to welcome you to a truly fascinating discussion on the cutting edge of longevity medicine. In this episode, I sit down with the brilliant Dr. Greg Kelly to explore the complex world of cellular senescence and its profound implications for our aging process. We delve into the challenges of identifying these aging cells and the exciting research that’s paving the way for more accurate biomarkers. I’m particularly excited to share with you Dr. Kelly’s insights on how simple lifestyle changes, such as incorporating regular exercise and mindful caloric intake, can significantly reduce the accumulation of senescent cells. We also discuss some groundbreaking interventions, including the use of senolytic agents like quercetin, dasatinib, and piper longumine, and how they’re revolutionizing our approach to longevity.

AI, Digital Twins, and the Future of Personalized Medicine Interventions with Dr. Nathan Price

AI, Digital Twins, and the Future of Personalized Medicine Interventions with Dr. Nathan Price

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I’m beyond thrilled to share this mind-blowing conversation with Dr. Nathan Price, Chief Scientific Officer of Thorne HealthTech and author of The Age of Scientific Wellness. Imagine harnessing AI to predict outcomes of our functional interventions (diet, supplements, lifestyle) by implementing a “digital twin” model that is populated with all of your patient’s bio data. Being able to test the response of our treatments (and importantly, the synergistic response of multimodal interventions! It’s heady stuff, but amazingly, it is where we are headed today. Dr. Price illuminates the incredible potential this technology brings for personalized evidence-based medicine in nutrition, tailoring interventions based on microbial markers, and addressing lifestyle changes for Alzheimer’s prevention. The podcast is a captivating exploration of cutting-edge concepts and provides a glimpse into the exciting future of healthcare. I was wowed by my convo with Nathan and can’t wait to start kicking the tires on this baby. I know you’ll feel the same.

Decoding Aging: The Science Of Cellular Rejuvenation With Dr. Vittorio Sebastiano

Decoding Aging: The Science Of Cellular Rejuvenation With Dr. Vittorio Sebastiano

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Why? Dr. Sebastiano has demonstrated in his laboratory that epigenetics, and primarily DNA methylation, is hierarchically dominant over all other hallmarks of aging. This is extraordinary. He has demonstrated in his laboratory (using Yamanaka factors) that when DNA methylation patterns are made more youthful, the other downstream hallmarks of aging also become more youthful.

Advanced Metabolomics: Identifying the Metabolic Signature for Aging with Betsy Redmond, Ph.D., MMSc, RDN

Advanced Metabolomics: Identifying the Metabolic Signature for Aging with Betsy Redmond, Ph.D., MMSc, RDN

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As functional practitioners, we’re compelled to understand the intricate changes in the aging journey that fuel the diseases we strive to prevent. The emergence of omics data, particularly metabolomics, marks a pivotal moment, and I’m thrilled to welcome back Dr. Betsy Redmond, a senior education specialist at Diagnostic Solutions Laboratory and a cherished friend, to New Frontiers. In this episode, we delve into the transformative power of metabolomics, emphasizing pathways over isolated metabolites for profound insights and more effective interventions. Welcome to Medicine 3.0, where we correct imbalances, identify metabolites linked to healthy aging, mood, gut health, and more, providing actionable steps to enhance both healthspan and lifespan. Plus, we’ll unravel some surprising insights from my own results! Join us for a wealth of valuable pearls to use in your practice. ~DrKF

New and Notable Studies Using Epigenetic Biological Age Clocks

Functional Medicine for Consumers, Functional Medicine for Professionals, Uncategorized1 Comment

This blog was written by Romilly Hodges MS CNS CDN IFMCP   Last month I was honored to be invited to speak at the American Nutrition Association annual summit on the topic Targeting Biological Age with Diet and Lifestyle. Not only was it a much-appreciated opportunity to connect face-to-face with colleagues, but it was also…

Breast Health and Beyond: A Practitioner’s Guide to Functional Testing

Breast Health and Beyond: A Practitioner’s Guide to Functional Testing

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Over 270,000 new cases of breast cancer are diagnosed each year in the US. And while BRCA mutations often get the most press, there are other, potentially more critical factors we can address. Today, Dr. Ruth Hobson joins us to delve into the realm of breast health, shedding light on both modifiable and non-modifiable risk factors, and sharing real-life strategies for supporting our patients. We dive into a range of essential topics, from dietary and lifestyle influences to the ongoing debate around Hormone Replacement Therapy (HRT), and venture into the world of functional tests to evaluate hormones and metabolites crucial for comprehensive breast health. We’ll uncover the intricate connection between gut health and breast health – Did you know that breast tissue has its own microbiome?!? – and examine how inflammation, peripheral fat, and methylation impact cancer risk. Bring a pen and paper, this is a deep dive into the hormones and breast health that you won’t want to miss. ~DrKF