NAD+ in the Spotlight: New Insights on Boosting Cellular Resilience

NAD+ in the Spotlight: New Insights on Boosting Cellular Resilience

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I’m really excited about this one—Dr. Greg Kelly is back with us, and we’re diving deep into NAD, a molecule that’s finally getting the attention it deserves. If you’ve heard me talk about NAD before, you know how foundational it is for energy, longevity, and cellular health, but I’ve got to say—after today’s conversation, I’m looking at it in a whole new way. Dr. Kelly brings a fresh perspective on how NAD influences mitochondrial function, DNA repair, and even the aging process. He’s challenging the way we think about aging, and I’m here for it. For me, NAD is no longer just a side player—it’s going front and center in my supplement stack. If you’re wondering how it might show up clinically, whether it’s in fatigue or other signs of cellular stress, you’ll want to listen in. And if you’re like me, you’ll be adding this one to your regular routine. Have a listen and get ready to rethink how you approach aging and energy. ~DrKF

The Future of Longevity: Science-Backed Biomarkers and Lifespan Strategies with Dr. Matt Kaeberlein

Promise and Controversies: State of the State of Longevity Science with Matt Kaeberlein, PhD

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We’re at an extraordinary inflection point in science, where our understanding of aging is evolving in ways that seemed unimaginable just a decade ago. As we explore these exciting advancements, we’re also faced with the challenge of defining key concepts like biological age, healthspan, and longevity interventions. In this episode, I’m joined by Dr. Matt Kaeberlein—one of my favorite voices in this space—for a far-reaching discussion. We dive into everything from aging as a programmed phenomenon to the latest clocks and even the supplements in his personal stack. I’m sure you’ll find this conversation as fascinating and insightful as I did. ~DrKF

Optimizing MS Care: Cutting Edge Insights with Dr. Terry Wahls

Latest Research Data on Diet & Other Interventions for Multiple Sclerosis with Dr. Terry Wahls

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Join us as we delve into cutting-edge clinical insights with Dr. Terry Wahls, exploring the forefront of multiple sclerosis management. We uncover the pivotal role of dietary patterns, from ketogenic protocols to the impact of olive oil versus coconut oil. Dr. Wahls shares exciting developments in plasma exchange and stem cell therapies, shedding light on their potential in autoimmune conditions and aging. We also explore the revolutionary Octave test, utilizing proteomics and AI to assess disease activity in MS patients. Join us as we navigate through personalized medicine challenges, biohacking for longevity, and the critical importance of adherence in therapeutic success. ~DrKF

Targeting Cellular Senescence for Healthier, More Youthful Skin

Targeting Cellular Senescence for Healthier, More Youthful Skin

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Today, we’re diving deep into a breakthrough in skincare science that has caught my attention—OneSkin’s OS-01 peptide. This episode explores how OS-01 targets cellular senescence, the core of aging, potentially transforming skin health.I’m particularly impressed by OneSkin’s commitment to rigorous research and evidence-based results. Their approach not only aims to rejuvenate skin but also enhances its natural radiance and elasticity. This could be a significant advancement for individuals managing aging skin or conditions like atopic dermatitis.

Unlocking Inflammation Resolution: The Power of Specialized Pro-Resolving Lipid Mediators with Ashley Koff

Resolving Chronic Inflammation using SPMs: A Two-Phase Approach with Ashley Koff RD

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If you’re looking to elevate your approach to inflammation and pain management, this episode is for you. Today, we dive into a fascinating conversation with registered dietitian Ashley Koff. We discuss the intricate role of specialized pro-resolving mediators (SPMs) and their potential applications in various health conditions, from inflammation and pain management to neurodegenerative diseases and autoimmune disorders. We also explore the nuances of gamma-linolenic acid (GLA) and its importance in functional medicine, particularly for women in perimenopause and menopause. If you’re curious about the latest insights on using SPMs in conditions like Lyme arthritis, chronic infections, and even concussions, this episode is packed with valuable information. We’ll also touch on practical strategies for incorporating these powerful molecules into your therapeutic protocols, ensuring your patients receive the most comprehensive care possible.

Mapping the Placental Methylome: The Key to Early Autism Intervention with Dr. Janine LaSalle

Towards Predicting Autism in Utero with Dr. Janine LaSalle

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This pioneer scientist mapped the human placental methylome. That is, all of the DNA methylation marks on the placenta, and has associated changes with neurodevelopmental disorders. She’s also demonstrated the influence of toxins and insufficient folate. Of the many implications inherent in her work, very exciting to me is the fact that we are moving toward in utero diagnostics using mom’s blood (ie, a standard blood draw). My hope is one day we will identify issues and address them all before baby is born!

Microbiome Reset: Building Childhood Resilience with Dr. Elisa Song

Smart, Actionable Strategies for Childhood Resilience, with Dr. Elisa Song

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I’m delighted to welcome back Dr. Elisa Song, a respected colleague and pioneer in pediatric functional medicine. Today, we’re delving into the critical intersection of the gut microbiome and pediatric health. In today’s landscape, families are confronted with daunting challenges. Between the 3000 chemicals hiding in ultra-processed foods, alarmingly high sugar content (sometimes as much as 14 teaspoons in a single drink!), and the pervasive presence of antibiotics in our food supply, it’s no surprise that we’re seeing negative changes in the microbiome, worsening metabolic health, increased allergies, autoimmune disease, and neurodevelopmental issues.

clocks

Past, Present, and Future of “Biological Aging” with Dr. Fitzgerald

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Team DrKF sat down with Dr. Fitzgerald to pose some questions about the “state of the state” of longevity research, current controversies and future directions, and where she sees her work fitting into it. When it comes to defining and using measures of biological age, where does the science currently stand? To understand where we currently stand, and why changes are afoot, we have to first consider where we’ve come from. When Steve Horvath at UCLA released the first epigenetic biological age clock in 2013 it marked the entry of longevity medicine into the mainstream (referred to as biogerontology in science, anti-aging medicine in some clinical circles).

Reducing Senescent Cell Accumulation for Enhanced Longevity with Dr. Greg Kelly

Targeting Senescent Cells? Dose and Timing Matters – with Dr. Greg Kelly

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I’m thrilled to welcome you to a truly fascinating discussion on the cutting edge of longevity medicine. In this episode, I sit down with the brilliant Dr. Greg Kelly to explore the complex world of cellular senescence and its profound implications for our aging process. We delve into the challenges of identifying these aging cells and the exciting research that’s paving the way for more accurate biomarkers. I’m particularly excited to share with you Dr. Kelly’s insights on how simple lifestyle changes, such as incorporating regular exercise and mindful caloric intake, can significantly reduce the accumulation of senescent cells. We also discuss some groundbreaking interventions, including the use of senolytic agents like quercetin, dasatinib, and piper longumine, and how they’re revolutionizing our approach to longevity.