Why Centenarians Are Defying Science: Secrets to Living 100+

Why Centenarians Are Defying Science: Secrets to Living 100+

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This conversation with Dr. Nir Barzilai is one of the most thought-provoking we’ve had on New Frontiers. His decades of research on centenarians, biological age, and the hallmarks of aging have shaped how we think about longevity—and what’s possible when we start targeting aging itself, not just individual diseases. We get into the science behind why some people live 20–30 years longer and healthier, and what it means to measure the biological age of individual organs. But we also hit a few sparks—especially when it comes to nutraceuticals and the role of metformin in prevention. I don’t agree with everything you’ll hear, and I followed up with Dr. Barzilai afterward to unpack some of the more provocative claims. We may just need a second round for this one… stay tuned.

The Science-Backed Bitter Compound That Mimics GLP-1 (No Injections Needed!)

The Science-Backed Bitter Compound That Mimics GLP-1 (No Injections Needed!)

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I’ve been watching the science behind Calocurb evolve over the last year, and I have to say—this is one of the most exciting clinical tools I’ve seen emerge in the metabolic space in quite some time. A hops-derived compound that stimulates endogenous GLP-1, CCK, and PYY—without a prescription or injection? That’s a big deal, especially for patients struggling with appetite regulation, weight plateaus, or the aftermath of GLP-1 discontinuation.

Why Human-Centered AI Is the Future of Medicine & Mental Wellness

Why Human-Centered AI Is the Future of Medicine & Mental Wellness

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This episode is a little different from what we usually cover on New Frontiers, but it’s one I couldn’t wait to bring to you. I’ve been thinking a lot about how we—as clinicians—are supposed to keep up in this era of high-throughput technology. We’re swimming in data: labs, multi-omics, diet logs… and an ever-growing stream from wearables. There’s just so much coming at us, and too often, we’re awash in a sea of information without adequate interpretive power.

Why You’re Aging Faster Than You Think & How to Slow It

Why You’re Aging Faster Than You Think & How to Slow It

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I’ve been looking forward to sharing this conversation with you because it’s one I’m truly passionate about. Today, we’re diving into the DunedinPACE epigenetic clock with one of its creators, the brilliant Dan Belsky. It’s a tool I use regularly with my patients, and one that’s transforming how we approach aging and interventions. While this show is a bit more technical than usual, the science is fascinating, and the real-world applications are incredibly valuable. This isn’t just about theory—it’s about practical insights that can change how we measure aging and track the effectiveness of the treatments we offer. Stick with us, and you’ll walk away with actionable knowledge that can make a difference in your practice. ~DrKF

toxic food new laws

Avoiding Toxic Food Chemicals Just Got a Bit Easier: New Laws & What You Need to Know

Functional Medicine for Consumers, Functional Medicine for ProfessionalsLeave a comment

When I was a kid at lunch, while my friends were eating those heavenly-looking ultraprocessed Twinkies and Ringdings and making dough balls with their white bread, I ate home-made yogurt or nutbutter sandwiches on a very dense, whole grain bread; or perhaps noshed on some sardines. Make no mistake, I went through a very rebellious phase involving Oreo cookies when I finally called the food shots in my life. But thankfully, I had gleaned enough from my mom that this phase didn’t last long. Indeed, I developed a deep appreciation for how savvy she was (and still is!) when it comes to keeping food clean, healthy and almost completely free of ultraprocessing and toxic food chemicals. She taught me the importance of avoiding ultra-processed foods and toxic food chemicals, long before it became a public health headline.

What Urinary Hormone Metabolite Testing Tells Us about Estrogen Metabolism and Breast Cancer Risk

What Urinary Hormone Metabolite Testing Tells Us about Estrogen Metabolism and Breast Cancer Risk

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Estrogen is a life-giving hormone with which modern humans have a complicated relationship. Over two decades ago, The Women’s Health Initiative (WHI) findings mistakenly reported that combined estrogen and progestin hormone therapy increased the risk of breast cancer, coronary heart disease, stroke, and venous thromboembolism in postmenopausal women. This led to a pervasive vilification of estrogen therapy that has affected generations of women.

The Shocking Truth About Chronic Illness: How to Reset Your Nervous System & Slow Aging

The Truth About Chronic Illness: How to Reset Your Nervous System & Slow Aging

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We’ve all had patients struggling with chronic conditions like long COVID, fibromyalgia, Lyme disease, and chronic fatigue. Despite all the tools in our functional medicine toolkit, there’s still something missing. How can we truly help them? I’m excited to have Ashok Gupta is back on the New Frontiers podcast to offer a new take on that healing from chronic illnessquestion. He explains that how many chronic diseases stem from a malfunction in the brain’s threat detection system, where the body overreacts to perceived threats, triggering immune, nervous system, or mood responses, . This creatinges a vicious cycle. Ashok shares how retraining the brain and calming the nervous system can reset the body’s response to chronic stress and presents the growing body of research supporting thehis Gupta Program, including new subjective measurements like CRP showing its impact. What excites me most is the potential for this approach to help some of my toughest-to-treat patients. With more studies emerging, I’m increasingly hopeful this could be a game-changer. It’s a conversation you won’t want to miss! ~DrKF

Next-Gen Alzheimer’s Testing: The Power of p-Tau 217 and Blood-Based Biomarkers

p-Tau 217: The Breakthrough Biomarker Revolutionizing Early Alzheimer’s Detection

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Join me for a fascinating conversation around an exciting breakthrough in dementia detection that’s offering real hope for early intervention. Dr. Hans Frykman, Chief Scientific Officer at Neurocode Laboratories, is here to share groundbreaking insights into cutting-edge biomarkers that can identify Alzheimer’s disease before symptoms even appear. What’s even more fascinating is how these same tools are revealing neuroinflammation caused by infections, including COVID, Lyme disease, and mold exposure—issues that are incredibly relevant in functional medicine today. The assays Dr. Frykman and his team have developed are transforming the way we think about diagnosing and addressing neurodegeneration. We’re talking about a potential game-changer that allows us to intervene earlier, reverse damage, and ultimately improve the trajectory of these conditions. This is an extraordinary time in science and medicine, and the work we’re discussing today is at the forefront of it all. Don’t miss out on how this could reshape your practice. ~DrKF