Reducing Senescent Cell Accumulation for Enhanced Longevity with Dr. Greg Kelly

Targeting Senescent Cells? Dose and Timing Matters – with Dr. Greg Kelly

I’m thrilled to welcome you to a truly fascinating discussion on the cutting edge of longevity medicine. In this episode, I sit down with the brilliant Dr. Greg Kelly to explore the complex world of cellular senescence and its profound implications for our aging process. We delve into the challenges of identifying these aging cells and the exciting research that’s paving the way for more accurate biomarkers. I’m particularly excited to share with you Dr. Kelly’s insights on how simple lifestyle changes, such as incorporating regular exercise and mindful caloric intake, can significantly reduce the accumulation of senescent cells. We also discuss some groundbreaking interventions, including the use of senolytic agents like quercetin, dasatinib, and piper longumine, and how they’re revolutionizing our approach to longevity.

AI, Digital Twins, and the Future of Personalized Medicine Interventions with Dr. Nathan Price

AI, Digital Twins, and the Future of Personalized Medicine Interventions with Dr. Nathan Price

I’m beyond thrilled to share this mind-blowing conversation with Dr. Nathan Price, Chief Scientific Officer of Thorne HealthTech and author of The Age of Scientific Wellness. Imagine harnessing AI to predict outcomes of our functional interventions (diet, supplements, lifestyle) by implementing a “digital twin” model that is populated with all of your patient’s bio data. Being able to test the response of our treatments (and importantly, the synergistic response of multimodal interventions! It’s heady stuff, but amazingly, it is where we are headed today. Dr. Price illuminates the incredible potential this technology brings for personalized evidence-based medicine in nutrition, tailoring interventions based on microbial markers, and addressing lifestyle changes for Alzheimer’s prevention. The podcast is a captivating exploration of cutting-edge concepts and provides a glimpse into the exciting future of healthcare. I was wowed by my convo with Nathan and can’t wait to start kicking the tires on this baby. I know you’ll feel the same.

Decoding Aging: The Science Of Cellular Rejuvenation With Dr. Vittorio Sebastiano

Decoding Aging: The Science Of Cellular Rejuvenation With Dr. Vittorio Sebastiano

It was a career-defining (and perhaps life changing) moment when Dr. Vittorio Sebastiano, a reproductive biologist by training, realized that because we are able to create life, that same body of information could be harnessed to create youth – that is, radically reverse our biological aging process to a younger time point without losing cellular identity. In 2014, he and his lab began unpacking this epiphany. They made the radical decision to conduct their investigations in human cells and tissue rather than in rodents, with the expectation that such a start would be a better bridge to human clinical trials. Flash forward a decade and Dr. Sebastiano and his team stand poised to begin trials in humans. Dr. Sebastiano is, in my opinion, one of the most extraordinary scientists in the longevity space today who flies under the radar of most of us in functional medicine.

Advanced Metabolomics: Identifying the Metabolic Signature for Aging with Betsy Redmond, Ph.D., MMSc, RDN

Advanced Metabolomics: Identifying the Metabolic Signature for Aging with Betsy Redmond, Ph.D., MMSc, RDN

As functional practitioners, we’re compelled to understand the intricate changes in the aging journey that fuel the diseases we strive to prevent. The emergence of omics data, particularly metabolomics, marks a pivotal moment, and I’m thrilled to welcome back Dr. Betsy Redmond, a senior education specialist at Diagnostic Solutions Laboratory and a cherished friend, to New Frontiers. In this episode, we delve into the transformative power of metabolomics, emphasizing pathways over isolated metabolites for profound insights and more effective interventions. Welcome to Medicine 3.0, where we correct imbalances, identify metabolites linked to healthy aging, mood, gut health, and more, providing actionable steps to enhance both healthspan and lifespan. Plus, we’ll unravel some surprising insights from my own results! Join us for a wealth of valuable pearls to use in your practice. ~DrKF

New and Notable Studies Using Epigenetic Biological Age Clocks

This blog was written by Romilly Hodges MS CNS CDN IFMCP   Last month I was honored to be invited to speak at the American Nutrition Association annual summit on the topic Targeting Biological Age with Diet and Lifestyle. Not only was it a much-appreciated opportunity to connect face-to-face with colleagues, but it was also…

Breast Health and Beyond: A Practitioner’s Guide to Functional Testing

Breast Health and Beyond: A Practitioner’s Guide to Functional Testing

Over 270,000 new cases of breast cancer are diagnosed each year in the US. And while BRCA mutations often get the most press, there are other, potentially more critical factors we can address. Today, Dr. Ruth Hobson joins us to delve into the realm of breast health, shedding light on both modifiable and non-modifiable risk factors, and sharing real-life strategies for supporting our patients. We dive into a range of essential topics, from dietary and lifestyle influences to the ongoing debate around Hormone Replacement Therapy (HRT), and venture into the world of functional tests to evaluate hormones and metabolites crucial for comprehensive breast health. We’ll uncover the intricate connection between gut health and breast health – Did you know that breast tissue has its own microbiome?!? – and examine how inflammation, peripheral fat, and methylation impact cancer risk. Bring a pen and paper, this is a deep dive into the hormones and breast health that you won’t want to miss. ~DrKF

Imprintome Mapping: Key to Evaluating Impact of Imprinted Genes on Aging and Disease with Dr. Randy Jirtle

Have You Met Your Imprintome Yet? Here’s Why You Should

I’m thrilled and honored to have Dr. Randy Jirtle join us again today on New Frontiers. Dr. Jirtle’s groundbreaking Agouti Mouse Study has shaped what we know about the influence of early life exposure on methylation and epigenetics. His (current work?/more recent work?), which involves mapping out the imprintome could be the key to understanding how our imprinted genes will influence aging and every known disease and disorder, providing hope that a clear pathway on how to optimize our health for better outcomes is in our future.

Harnessing Nutrient Responsive Genes Against Breast Cancer

I am particularly interested in nutrient responsive genes, especially for altering the risk for and course of conditions such as breast cancer. Nutrient responsive genes, as their name implies, are those whose expression responds to their environment – specifically the nutrients we ingest. This effect is mediated via epigenetic alterations induced by those nutrients. This…