I am particularly interested in nutrient responsive genes, especially for altering the risk for and course of conditions such as breast cancer. Nutrient responsive genes, as their name implies, are those whose expression responds to their environment – specifically the nutrients we ingest. This effect is mediated via epigenetic alterations induced by those nutrients. This…
Over the last decade, there has been an explosion of research looking at bioenergetics (energy metabolism) and the role our energy generators – the mitochondria – play in human health and longevity. In functional medicine, we’ve long been aware of bioenergetics – the need to “tend to our patient’s mitochondrial health,” and as such, we readily employ a litany of nutrients – from CoQ10 to carnitine and lipoic acid and others – whenever we deem them indicated. There have not been, however, many nutrients to blast onto the bioenergetics center stage with quite the impressive force as the postbiotic rock star Urolithin A. With studies published in top-tier journals such as Nature and Cell – and with 11 (yes, eleven) compelling human clinical trials – if this compound hasn’t made it to the top of what you’re using for patients (and taking yourself), read on.
Midlife is an extremely active time epigenetically. Pro-inflammatory genes tend to become hypomethylated and get ramped up, tumor-suppressor genes can become progressively more silenced, genes that code for antioxidant and detoxification enzymes such as glutathione transferase (which also happens to be an important tumor-suppressor gene!) also get dialed down, and genes that promote cancer (known…
This is a quick and simple way to get in a large amount of your epinutrient-rich foods for the day and is my go-to breakfast and lunch combo. You can absolutely customize this to accommodate what you have in your fridge—I’ve included a base template below, before the actual recipe, so that you can see…
Last month, I was awarded the Rosalind Franklin Society Special Award in Science for my research on using a diet and lifestyle program to favorably change DNA methylation and reverse biological aging. I’m humbled and honored to receive this award, which is given to the top papers of the year written by women or underrepresented…
Mushrooms are a powerful, and often underutilized, tool for health and longevity. They provide important nutrients, including those used in methylation cycles- folate, choline, and zinc for example. Their bioactive compounds also act as DNA methylation adaptogens, with the ability to influence gene expression and even potentially biological age. It’s why mushrooms feature as one…
Buckle up everybody, because this conversation is a big tour de force of where we are headed in regards to longevity and innovative technology within healthcare. I am joined by my friend, longevity investor and visionary, Sergey Young, to discuss his incredibly important mission of extending healthy lifespans of at least one billion people using technological breakthroughs AND by making longevity affordable and accessible. Sergey is a top 100 longevity leader and one of the co-creators of AGE REVERSAL XPRIZE, a global competition designed to cure aging. Today’s conversation looks at the fundamental issue of healthcare inequality, the democratization of access to healthcare, and dives into the current paradigm shift of using technology for disease prevention and reversal of biological aging. I’m sure you’ll enjoy this conversation as much as I did, and be wowed by the work of Sergey Young. ~DrKF
Eggs are one of those controversial foods that we were warned against for almost half a century. However, recent years have seen both the American Heart Association and Dietary Guidelines for Americans reverse their restrictions on eggs and dietary cholesterol intake. Rightly so – the evidence didn’t support them, and their redirected emphasis on dietary…
The therapeutic value of curcumin makes it a fabulous recommendation as both a foundational and medicinal supplement. And since finding a preparation that is bioavailable is key to efficacy, affordability, and patient compliance, I’m excited to have Dr. Sonia Malani (on behalf of Integrative Therapeutics) here to talk about the latest advances in curcumin deliverability and why it matters. Join us as Dr. Malani breaks down the progress of curcumin deliverability and the keys to bioavailability in a way that is simple to understand and easy to pass on to our patients in order to help them move away from the ineffective brands that are currently lining the shelves of local markets so they get the therapeutic influence we are hoping for. I know you’ll enjoy this curcumin talk, and learn a ton from this latest research. Thanks for listening! ~DrKF
If you’ve followed my show for some time, you’ve probably come across the wealth of conversations I’ve had with the team at Precision Analytical about their DUTCH hormone tests – this is an ever-evolving topic that continues to pique my interest as a clinician looking to level up my toolkit. In today’s show, I’m pleased to dive into some of my favorite topics of fertility, menopause, and HPA function with Dr. Jaclyn Smeaton, ND. She’s the chief medical officer at Precision Analytical, and a naturopathic physician who specializes in reproductive endocrinology and hormones. Today’s conversation is all about the latest research on hormone testing, some of our favorite interventions to address hormone imbalances and much more as you consider the best testing options for your patients. This is an incredibly useful conversation so make sure to tune in! ~DrKF
