Wow, I am beyond honored that the great Dr. Artemis Simopoulos joined me on New Frontiers. Basically, if you’re thinking about omega 3 and omega 6 fatty acids, it’s because of the pioneering work of this scientist. Hear how she figured out the importance of omega 3 fatty acids in a riveting tale of following the data, following hunches and importantly, asking the questions.
Dr. Fahy’s research was the first to demonstrate the potential of biological age reversal as measured by all epigenetic clocks available in 2019. This was an extraordinarily exciting moment in science.Hear all about that journey and what he and his team are working on now. Still underappreciated (in my opinion) is the fact that his protocol regenerates the thymus gland in older individuals. The implications of this are massive.
This pioneer scientist mapped the human placental methylome. That is, all of the DNA methylation marks on the placenta, and has associated changes with neurodevelopmental disorders. She’s also demonstrated the influence of toxins and insufficient folate. Of the many implications inherent in her work, very exciting to me is the fact that we are moving toward in utero diagnostics using mom’s blood (ie, a standard blood draw). My hope is one day we will identify issues and address them all before baby is born!
I am paying attention closely to research coming from the largely untapped world of postbiotic compounds and their essential role in human physiology. I have had the honor to talk quite a few times with Dr. Anurag Singh, and always the clinical (and preclinical) research that he and his team are up to looking at postbiotic wunderkind urolithin A (a compound produced by GI bacterial action on precursor compounds found in pomegranate) are thrilling, powerful and illustrate how wildly important these compounds are in human physiology
Why? Dr. Sebastiano has demonstrated in his laboratory that epigenetics, and primarily DNA methylation, is hierarchically dominant over all other hallmarks of aging. This is extraordinary. He has demonstrated in his laboratory (using Yamanaka factors) that when DNA methylation patterns are made more youthful, the other downstream hallmarks of aging also become more youthful.