Early Cytokine Signatures Predict COVID Severity and May Guide Interventions

According to this new Nature paper, those with severe COVID are spiking higher cytokine signatures early on. This would suggest value in testing, including possibly IFN-gamma (see below), and addressing it early through anti-inflammatory diet and lifestyle, as well as targeted anti-inflammatory nutraceutical interventions. This is, of course, a ‘standard’ approach used in Functional Medicine,…

Organs targeted by ACE-2-utilizing viruses like COVID-19

This infographic from Scientist illustrating the many organs that the virus can gain entry to using ACE2 or TMRPSS2 receptors (definitive evidence for viral presence in the various organs is still being established, but the presence of the receptors provides a road map for investigation). Certainly this influences the wide variety of COVID presentations we…

Can Unconventional Immunomodulatory Agents Help Alleviate COVID-19 Symptoms and Severity?

ABSTRACT Severe acute respiratory syndrome coronavirus 2 (SARS coronavirus 2, or SARS-CoV-2) is the cause of the respiratory infection known as COVID-19. From an immunopathological standpoint, coronaviruses such as SARS-CoV-2 induce increased levels of a variety of T-helper 1 (Th1) and inflammatory cytokines and chemokines, including interleukin-1 (IL-1), IL-6, CCL2 protein, and CXCL10 protein. In…

The Functional Medicine Approach to COVID-19: Additional Research on Nutraceuticals and Botanicals

In this paper, the Institute for Functional Medicine (IFM) added to the list of nutraceuticals and botanicals introduced earlier in their first article, The Functional Medicine Approach to COVID-19: Virus-Specific Nutraceutical and Botanical Agents. Periodically, IFM will update the original list to highlight other agents that may be considered as complementary treatments against COVID-19. Along…