My research and analysis on the important connections between furin and SARS CoV-2 has been accepted as a preprint article on SSRN. Thank you, David Riley, for making that happen! Abstract: Furin is a protease that is ubiquitous in the mammalian metabolism. One of the innovations that make SARS-CoV-2 more infectious than its ancestor viruses…
From the folks that brought us Specialized Pro-resolving Lipid Mediators (SPMs), comes a new peer-reviewed paper that highlights the potential for SPMs in addressing pro-inflammatory cytokine production and cytokine storm in COVID-19. SPMs stimulate macrophage-mediated clearance of cellular debris and reduce pro-inflammatory cytokine levels. They also promote anti-viral B cell antibodies and other white blood…
ABSTRACT Severe acute respiratory syndrome coronavirus 2 (SARS coronavirus 2, or SARS-CoV-2) is the cause of the respiratory infection known as COVID-19. From an immunopathological standpoint, coronaviruses such as SARS-CoV-2 induce increased levels of a variety of T-helper 1 (Th1) and inflammatory cytokines and chemokines, including interleukin-1 (IL-1), IL-6, CCL2 protein, and CXCL10 protein. In…
