The gut is a major site for IgE-producing B cells in peanut-allergic patients, defined for the first time by new research. The authors also found evidence suggesting that isotype switching can occur in GI tissue – including switching from IgA and IgG to IgE immunoglobulin types. This new understanding presents opportunities for future interventions to be developed to block immunoglobulin type switching.
Peanut IgE+ B Cells Aren’t Just in Blood
