The “dance of methylation” extends far beyond supplementing with B12 and methylated folate. Indeed, long term outcome studies using this approach are lacking, and research suggests caution is advised with regard to imbalanced hypermethylation. However, much can be done to safely support methylation balance.
Sparing “methyl donor drain” through appropriate lifestyle interventions, including reducing total body inflammation, augmenting the microbiome and promoting exercise, stress reduction and sufficient sleep, along with a careful dietary prescription that supports methyl donor reserve is a safe, nuanced approach which allows the complex, homeodynamic process of methylation to take place.
In The Methylation Diet and Lifestyle, you will find:
- 140 Pages with over 150 References
- An explanation of the functions of methylation in the body, as well as its biochemistry and nutrient requirements
- A description of the clinical problems surrounding methylation, including MTHFR and other gene SNPs and nutrient deficits
- A comprehensive discussion of the pros and cons of supplemental methylation nutrients (including folic acid vs 5mTHF), as well as a review of the literature that strongly suggests we should proceed with caution in pushing enzymatic reaction rates, to avoid hypermethylation states
- How to approach methylation assessment in a more comprehensive manner, including genetics, metabolic markers, nutrient status and more
- What foods provide safe forms of methylation-related nutrients, and dietary patterns that support healthy methylation
- How lifestyle factors such as stress and exercise, and other physiological conditions such as inflammation, oxidative stress, toxin exposure, microbiome imbalance and malabsorption can impact methylation status and what to advise
- Two 7-day menu plans (one gluten- and dairy-free, one Paleo) with over 40 recipes, and detailed nutrient analysis so you know how much of each methylation nutrient is provided
- Practitioner checklists for assessment and intervention options