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Dr. Kara Fitzgerald
Individualized Evidence Based Integrative & Functional Medicine
Dr. Kara Fitzgerald Dr. Kara Fitzgerald
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      • Younger You Book
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    • REPORT: The Use of AI & Wearables in Functional & Longevity Medicine
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  • YOUNGER YOU
    • Practitioner Training
    • What is Younger You
    • Books
      • Younger You book
      • Better Broths and Healing Tonics Book
    • Discover Your Bio Age
      • Bio Age Quiz (BASA) – FREE
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      • 10-Day Self-Paced Course
      • 1-1 Clinic Support
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Dr. Kara Fitzgerald Recommended Links

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View allAllergy ResourcesBotanical Medicine ResourcesFind an Integrative DentistIntegrative & Functional Medicine Education & ReferenceIntegrative & Functional Medicine ResourcesMedical ResourcesNutrition ResourcesNutritional Biochemistry & Metabolic PathwaysScience ResourcesShopping ResourcesToxicity Resources

Food-Pollen Cross Reactions

Pollen allergic people may experience symptoms when they eat certain fruits, vegetables, spices, and nuts. It is called cross-reactions.

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Food Allergy Research & Education (FARE)

Alletess Medical Laboratory specialize in food and inhalant allergy testing, food sensitivities and other tests to assess the immune system.

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AllergyMoms Support Group

The AllergyMoms website provides support for parents of kids with food allergies. Visit Site

KARA FITZGERALD, ND
DR. KARA FITZGERALD, LLC
KF EDUCATION & CONSULTING, LLC

The New Frontiers Functional Medicine & Nutrition Clinic is located in the Sandy Hook Village section of Newtown, Connecticut in Fairfield County, Connecticut.
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    (203) 304-9502
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    27 Glen Road, Sandy Hook CT 06482

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IFM Certified Practitioner

Kara Fitzgerald, ND, Naturopathic Doctor is a certfied practitioner with The Institute for Functional Medicine.

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It’s not A1C. Not LDL. It’s Lipopolysaccharide (LP It’s not A1C.
Not LDL.
It’s Lipopolysaccharide (LPS).

An endotoxin that enters circulation when gut barrier function is compromised, quietly driving systemic inflammation.

And the data are hard to ignore:
→ In a 9-year cohort, LPS was the only biomarker that predicted both the presence and severity of anxiety and depression
 → Tracks with progression from prediabetes to diabetes
 → Drives hypothalamic inflammation → central insulin resistance
 → Associated with chronic low-grade inflammation and even skin conditions like acne

In women, this becomes especially relevant.
As estrogen declines in peri- and menopause:
 ↓ microbiome diversity
 ↑ intestinal permeability
 ↑ LPS translocation
Shifting the body toward a more inflammatory, catabolic state.

LPS isn’t just a marker. It’s a signal.

And if you’re not addressing it, you may be missing a root driver of metabolic and neurological decline.

COMMENT NITRIC or head to https://www.drkarafitzgerald.com/2026/05/05/perimenopause-gut-cardiovascular/) for my full conversation with @kiranbiome from @calroyhealthsciences. 

#FunctionalMedicine #LongevityScience #GutHealth #Microbiome #Inflammation #Perimenopause #HealthyAging #PrecisionMedicine #MetabolicHealth #BrainHealth
It all starts with mom, even your cells. 🧬💛 Today It all starts with mom, even your cells. 🧬💛

Today I’m thinking about something pretty amazing: all of our mitochondria, the little engines that power every cell in our body, come directly from our mothers.

It’s a reminder that the energy we use to move through the world, to heal, to thrive; it all begins with them.

So here’s to the moms, grandmothers, and mother figures who gave us more than we can ever fully appreciate, starting with the very first spark.

Happy Mother’s Day. 🌸
How you brew your coffee matters more than you thi How you brew your coffee matters more than you think.

Unfiltered methods (French press, espresso) let a compound called cafestol through, which has been shown to raise LDL by ~5–10 mg/dL in clinical trials.

Paper filters? They trap most of it.

In a 20-year study of 500,000+ people, filter coffee was linked to lower mortality, while unfiltered showed a signal toward higher cardiovascular risk in older men.

This isn’t about cutting coffee; it’s about how you make it.

If you’re watching lipids or cardiovascular risk, a simple switch to paper-filtered coffee may be worth considering.

#CoffeeScience #EvidenceBased #LongevityScience #HeartHealth #CardiovascularHealth #CholesterolSupport #LDL #PreventiveHealth #FunctionalMedicine #ClinicalInsights #HealthOptimization #WellnessEducation #NutritionScience

Sources: Tverdal, Eur J Prev Cardiol, 2020, Cai, Eur J Clin Nutr, 2012, Cornelis & van Dam, J Nutr, 2020, Urgert, BMJ, 1996, Ludwig, Food & Function, 2014, Orrje, Nutr Metab Cardiovasc Dis, 2025, RendĂłn, Food Res Int, 2017
Alcohol consumption is shifting, and quickly. Rec Alcohol consumption is shifting, and quickly.

Recent data suggests fewer Americans are drinking, and younger generations are leading the change. But the conversation deserves nuance.

Yes, alcohol is a known carcinogen.
Yes, even moderate intake carries measurable risk.
And yes, our understanding of alcohol and health has evolved significantly over the last decade.

But behavior change isn’t just about fear or headlines. It’s about informed, sustainable choices.

In clinical practice, I see a growing number of patients asking better questions:
How does alcohol affect my hormones?
My sleep?
My long-term disease risk?

This is where the real opportunity lies, not in absolutism, but in awareness.

If you choose to drink, do so intentionally.

If you’re reconsidering your relationship with alcohol, you’re not alone.

This is what a more informed, prevention-focused culture looks like.

Source: Source: Gallup Poll, 2026 (U.S. adults) https://news.gallup.com/poll/693362/drinking-rate-new-low-alcohol-concerns-surge.aspx

#functionalmedicine #longevity #womenshealth #brainhealth #epigenetics #preventivemedicine #alcoholawareness
Colon cancer at 35. A legacy herbicide. And the ep Colon cancer at 35. A legacy herbicide. And the epigenome holds clues. 🧬 Read to the end.

⬇️⬇️⬇️

A recent paper in Nature Medicine adds an important layer to how we think about environmental exposures and early-onset cancer.

Researchers used epigenetic profiling to compare tumor tissue from individuals under 50 with those over 70 and identified distinct exposure-linked signatures.

One signal that emerged in the analysis: Picloram, a herbicide first introduced in 1963 and still in use today.

📊 Context from the data
 • Rising rates of colorectal cancer in younger populations
 • Geographic variation in incidence alongside agricultural use patterns
 • Associations that persisted after adjusting for multiple confounders

đź§  Why this matters clinically
For years, I’ve emphasized that environmental inputs can influence gene expression not only through direct toxicity, but through epigenetic signaling: subtle, cumulative shifts in how genes are regulated over time.

This study doesn’t establish causation. But it does highlight something I believe is critical: 👉 Our exposures may leave biological “imprints” that are measurable in human tissue.

đź’ˇ The bigger picture
 What’s most compelling here is the approach: using epigenetic patterns within tumors to better understand long-term environmental influences.

If validated and refined, this could expand how we evaluate chemical safety, moving beyond short-term toxicity toward long-term biological impact.

💬 I’m curious. Does this shift how you think about environmental exposures and risk?

♻️ Share with a colleague who’s thinking about early-onset disease.

Source: https://doi.org/10.1038/s41591-026-04342-5

#epigenetics #environmentalhealth #longevityscience #functionalmedicine #preventivemedicine #healthspan
This website is for informational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always consult your physician with any questions regarding a medical condition.
Dr. Kara Fitzgerald

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Dr. Kara Fitzgerald, ND

Dr. Fitzgerald is an internationally-recognized expert clinician, as well as nationally-bestselling author, who is actively engaged in clinical research on epigenetics and longevity using a diet and lifestyle intervention developed in her research and practice.

She has published two clinical studies on the potential bioage-reversing effects of an 8-week DNA methylation-supportive diet and lifestyle in middle-aged men and women in the journal Aging. She continues to lead the conversation around interventions for healthy aging and their extensive potential in improving individual and population level disease burdens, while also providing evidence-based and practical advice that cuts through the hype.

Dr. Fitzgerald is on faculty at the Institute for Functional Medicine (IFM), is an IFM Certified Practitioner, and lectures globally on functional medicine, longevity, and epigenetics to practitioners and consumers.

She maintains an award-nominated podcast series ranked in the top 1% of global podcasts by Listen Score, New Frontiers in Functional Medicine, and an active blog and Clinic Immersion webinar series through her website, www.drkarafitzgerald.com.

Follow Dr. Fitzgerald on Instagram: @drkarafitzgerald

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