Having Two ApoE4 Gene Alleles Appears to Double the Risk for Severe COVID-19

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Having Two ApoE4 Gene Alleles…

ApoE4 is known for increasing the risk for dementia. New analysis of UK data suggests that it may also increase the risk for more severe outcomes from COVID-19 – double that of those with the ApoE3 gene variants. This finding held true independently of pre-existing dementia, cardiovascular disease and type 2 diabetes.

More research is needed to confirm the association and to understand the biological mechanisms that may be at play.

https://www.theguardian.com/world/2020/may/26/research-reveals-gene-role-in-both-dementia-and-severe-covid-19?CMP=Share_iOSApp_Other

Tags: apoe4 COVID dementia Diabetes

Author: Kara Fitzgerald, ND

https://www.drkarafitzgerald.com/

Kara Fitzgerald, ND, received her doctor of naturopathic medicine degree from the National University of Natural Medicine in Portland, Oregon. She completed the first Counsel on Naturopathic Medicine-accredited post-doctorate position in nutritional biochemistry and laboratory science at Metametrix Clinical Laboratory under the direction of Richard Lord, PhD. Her residency was completed at Progressive Medical Center, a large, integrative medical practice in Atlanta, Georgia. Dr. Fitzgerald is the lead author and editor of Case Studies in Integrative and Functional Medicine and is a contributing author to Laboratory Evaluations for Integrative and Functional Medicine and the Institute for Functional Medicine (IFM)’s Textbook for Functional Medicine. With the Helfgott Research Institute, Dr. Fitzgerald is actively engaged in clinical research on the DNA methylome using a diet and lifestyle intervention developed in her practice. The first publication from the study focuses on reversal of biological aging and was published 04-12-2021 in the journal Aging. She has published a consumer book titled Younger You as well as a companion cookbook, Better Broths and Healing Tonics and has an application-based Younger You Program, based on the study. Dr. Fitzgerald is on the faculty at IFM, is an IFM Certified Practitioner and lectures globally on functional medicine. She runs a Functional Nutrition Residency program, and maintains a podcast series, New Frontiers in Functional Medicine and an active blog on her website, www.drkarafitzgerald.com. Her clinical practice is in Sandy Hook, Connecticut. Additional publications

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“After years of working alongside Dr. Fitzgerald on reaching and maintaining optimal health, I can safely say she is one to look out for to not only live a longer life, but a healthier and more vibrant one.”

Amy Myers, MD, New York Times bestselling author of The Autoimmune Solution and Thyroid Connection

“It is a new era—aging ‘backward’ is no longer a fantasy, it is now a fact proven by clinical trial. Dr. Kara Fitzgerald, lead author of this paradigm-shifting trial, now describes her approach in her new book, Younger You. This is the first book in the new era of ‘aging reversal’ medicine and health, and for all of us who are aging, this is a must-read.”

Dale Bredesen, MD, professor and author of the New York Times bestseller, The End of Alzheimer’s