Having Two ApoE4 Gene Alleles Appears to Double the Risk for Severe COVID-19

ApoE4 is known for increasing the risk for dementia. New analysis of UK data suggests that it may also increase the risk for more severe outcomes from COVID-19 – double that of those with the ApoE3 gene variants. This finding held true independently of pre-existing dementia, cardiovascular disease and type 2 diabetes.

More research is needed to confirm the association and to understand the biological mechanisms that may be at play.

https://www.theguardian.com/world/2020/may/26/research-reveals-gene-role-in-both-dementia-and-severe-covid-19?CMP=Share_iOSApp_Other

Author: Kara Fitzgerald, ND

https://www.drkarafitzgerald.com/

KARA FITZGERALD, ND completed a post-doctorate in nutritional biochemistry/laboratory science with Richard Lord, Ph.D. Author: Case Studies in Integrative and Functional Medicine, contributing author: Laboratory Evaluations for Integrative and Functional Medicine; IFM’s Textbook for Functional Medicine. She lectures globally on functional medicine; is on faculty at IFM and practices in Connecticut.

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It’s time that we, practitioners, re-consider the approach that ‘pushing’ methylation reactions with supplementation alters epigenetic methylation expression. In their new eBook, Fitzgerald and Hodges explain how to support epigenetic and metabolic methylation. Learn how to support methylation the RIGHT WAY with The Methylation Diet and Lifestyle — a smart, safe plan that includes diet, exercise, gut health, stress, resilience, sleep and ways to limit “methyl donor drain.

Patrick HanawayMedical Director, Center for Functional Medicine, Cleveland Clinic

The central role that methylation plays demands more careful attention than simply reaching for supplements. That’s why I’m excited to incorporate the ideas from the new eBook for cliniciansThe Methylation Diet and Lifestyle into my own practice. In this book, Dr. Fitzgerald and Romilly Hodges explain how to use a broader and safer approach to healthy methylation expression, including diet, limiting methyl donor drain, stress response, exercise and gut health. It’s a must-read!

Dr. Mark Hyman, MD9 Time NY Times Best Selling Author

I LOVE LOVE LOVE your new ebook, Methylation Diet & Lifestyle! It’s brilliant! Kara and Romilly make a complex biochemical subject easy to understand. I love your explanation of methylation, the nuance and distinctions like considering the complex interplay among the SNPs, the needed nutrients, and the food recommendations! It’s a must read for practitioners and patients.” – Certified Nutrition Consultant and Author of Nourishing Hope for Autism.

Julie MatthewsCertified Nutrition Consultant

These days, methylation is a ‘hot’ topic in functional medicine: everyone knows it’s important, but there is debate about which is the most effective clinical protocol is for the best outcome. What I like about the Methylation Diet and Lifestyle E-book is that it takes a whole-self, lifestyle-medicine approach to this complicated area of clinical medicine and makes it actionable for the millions of us with variability in our ability to detoxify through methylation. This 140-page report is grounded in practical steps to get those with methylation deficits on their way to feeling empowered and healthy.

Dr. Deanna MinichAuthor of Whole Detox

Dr. Fitzgerald’s book is an extraordinary integration of a vast amount of diverse information that makes practical sense of the complex interplay between our genes, the folate/vitamin B12 cycle, homocysteine, and the clinical importance of methylation.

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The Methylation Diet and Lifestyle Book contains “news to use” that makes the very complex human biochemistry story of methylation reader friendly. It is a wonderful introduction to how nutrition and lifestyle can influence the epigenetic regulation of gene expression.

Jeffrey Bland, PHDPresident

Finally, an easy to read and understand explanation of methylation that is suited for both clinicians and the public. In Methylation Diet and Lifestyle, Dr Kara Fitzgerald demystifies the genetics and offers a rational approach that steers away from high dose supplementation as the answer, and instead focuses on using food as medicine. Thank you for bringing balance to this conversation!

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It takes a special skill to be able to make the complex understandable and accessible without losing the original essence. Kara has that skill in abundance and her Methylation book is a latest shining example. She has a rare gift to impart the tenets of Functional Medicine and produce brilliant guides and case studies, and in this field I have been fortunate to learn more from her writings and lectures than from any other professional. I have been involved with nutrigenomics professionally for a number of years, and I can honestly recommend this book wholeheartedly no matter how experienced the reader. This is a book that works on many different levels and is representative of standards that all writers in the genre should aspire to.

Jonathan Cohen MSc mBANT, NGC, rCHNCClinic Director - Can Health

A methylation masterpiece! This comprehensive, user-friendly guide covers the methylation landscape from nutritional biochemistry to application in practice. The methylation assessment checklist, whole foods menu rich in methylating nutrients and delicious recipes are essentials for your clinical toolkit. A ‘must-have’ educational resource that provides the ‘much needed’ clarity we’ve been searching for!

Kathie Swift MS RDN LDN FANDCo-Founder IFN Academy

This book provides the tools you need to make an important contribution to your health, by understanding and applying the nutritional and lifestyle factors that impact the methylation process in every cell of your body.

Jeffrey Bland, PHDPresident

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Having Two ApoE4 Gene Alleles Appears to Double the Risk for Severe COVID-19

Author: Kara Fitzgerald, ND

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