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Using Metabolomic Analysis For Clinical Insight

So many of us in functional medicine use urine organic acids as an assessment tool, yet we rarely pause to think how they are so intricately connected with the wider world of applied metabolomics. And we should because research shows that a broader view of metabolomics (i.e. not just your standard organic acid markers) results in a six-fold higher diagnosis rate compared to traditional assessment methods. Impressive, isn’t it? I’m thrilled to be joined by my dear friend and metabolomics expert Dr. Betsy Redmond in today’s podcast.

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What does “Evidence-based” look like in Functional Lab Testing?

As the name suggests, New Frontiers is about staying ahead of the curve in functional medicine, continually asking critical questions, and being open to self-critique. This couldn’t be more true than when it comes to advanced functional testing. Today I’m pleased to talk with a familiar face and renowned hormone testing expert, my friend Mark Newman. Mark created the DUTCH test based on his decade-long experience in novel test development, and joins New Frontiers to talk about all things hormones: from cortisol & thyroid health to estrogen, progesterone and androgens, the importance of analytical and clinical validation of tests, and his upcoming research on various hormone replacement therapy methods.

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Exploring Longevity Medicine and Epigenetic Aging with Dr. Lucia Aronica

What can queen bees teach us about epigenetics? And what do polyphenols, stress, and sunlight have in common? Hint: it has to do with longevity science. To mark our exciting paper on the Potential Reversal of Epigenetic Age Using a Diet and Lifestyle Intervention we are hosting a series of podcasts focused on the science of epigenetics and longevity, and kick things off with talented researcher and Stanford lecturer, Dr. Lucia Aronica. Dr. Aronica is a passionate advocate of lifestyle medicine and is currently leading the epigenetic analysis for the largest randomized clinical trial in the field of personalized nutrition on low carb vs. low fat diets.

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Comparing Saliva, Urine, and Serum Hormone Testing: Choosing the Best Test for Each Patient

Have you ever looked at serum hormone levels and scratched your head, wondering why there was such a difference between your patient’s clinical signs and the numbers on the report? Felt unsure whether to look at bioavailable hormone markers or their metabolites? Not surprisingly, when it comes to endocrinological health, there are just as many questions as hormones (and there are over 50!). My guest in this podcast, Dr. Lylen Ferris, gives us very clear and user-friendly guidance on appropriate hormone testing, interpreting results from different specimens and, most excitingly, using novel biomarkers, such as allopregnanolone. Having completed her naturopathic residency with Dr. Kimberly Windstar, and after years of teaching and mentoring medical students on gynecology and women’s health, Dr. Ferris has plenty of brilliant clinical pearls to share with us! Please share, comment, and leave us a starred review if you wouldn’t mind! Thank you!

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The Cell Danger Response: Restoring Cellular Health with Phospholipids and Bioactive Lipids

I am always eager to learn from other clinicians about how they approach complex patients and layer various healing modalities into the therapeutic encounter. My guest today, Dr. Bruce Hoffman MD, has combined his passion in integrative medicine with psychiatry to explore cellular health to best guide his patient’s health journey. Dr. Hoffman is based in Calgary, Canada at the Hoffman Centre for Integrative Medicine and the Brain Center of Alberta. He’s an IFM-certified functional medicine practitioner, board-certified in anti-aging and regenerative medicine (Shoemaker’s mold protocol), a certified Ayurvedic practitioner (Bredesen’s ReCODE treatment), certified as a family constellation therapy specialist, (ILADS for Lyme and co-infections), and trained in Chinese medicine, to name just a few of his substantial specialties. He knows his stuff. Tune in for this thought-provoking conversation as we explore the role the psyche plays in disease and healing, including clinical pearls, interventions, and effective supplementation. Listen, share, and leave a starred rating, if you wouldn’t mind! Thanks for listening.

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Integrative Protocols: Focus on Senolytics, Cell Senescence, and the Role of Telomerase Activation

Colleagues, if you’ve been following me for any time, you’ve heard me speak frequently about aging as the top driver of chronic disease. In today’s interview, I dive into evidence-based integrative protocols to prevent and reverse the aging process. My guest, Dr. Joseph Cleaver MD, is a Fellow of the American Board of Anti-aging and Regenerative Medicine, is board-certified in internal medicine, a rheumatologist, on faculty at A4M and MMI and has authored and published a wealth of research and scholarly articles. He founded Paradigm Wellness Medical Group in Dallas and Sonoma Valley, California, AND he is Medical Director at Boutique Wellness in Winston, North Carolina. Folks, you’ll want to be ready to take notes during this interview, as Dr. Cleaver shares his personalized senolytic protocols specific to patient phenotypes. Listen, share, and leave a starred rating, if you wouldn’t mind! Thanks for listening. ~DrKF

Episode 69: Sponsored | Telomere Integrity: What Clinicians Need to Know with Dr. Joseph Raffaele

Sponsored |The Best Biomarker of Aging: What Clinicians Need to Know

I am particularly fascinated by new advances in testing biological age and how these biomarkers relate to disease risk. My podcast guest today is Dr. Joseph Raffaele MD, a leading expert, researcher, and clinician on the topic of biological aging and telomeres. We talked last year on New Frontiers, and I’m psyched to continue the conversation!

This time, Dr. Raffaele and I explore the various tests he uses to determine physiological age and disease risk, and go big into how senescent T cells and infections, such as cytomegalovirus, increase COVID-19 risk, particularly in a younger, seemingly healthy population. You’re going to love this enticing convo on the role of aging as it relates to disease and COVID-19 risk, and might find some great take-away clinical pearls to use in your own practice. Settle in, this is a good one, and let me know what you think by leaving a review or comment! ~DrKF

Got Good Guts? Clinically Effective Applications for SIBO, SIFO, and Dysbiosis

Episode 78: Sponsored | Got Good Guts? Clinically Effective Applications for SIBO, SIFO, and Dysbiosis

Dr. Jocelyn Strand is the Director of Clinical Education at Bio-Botanical AND a great clinician herself. Prepare yourself: this is a very actionable podcast for clinicians using bioB. And for me, a huge pearl on refractory SIBO was unaddressed oral microbiome! In this episode of New Frontiers, learn how Dr. S addresses sibo using BB products. To test or not to test?

The Business of Functional Medicine: Secrets for Success for your own FxMed Practice

Episode 76: Sponsored | The Business of Functional Medicine: Secrets for Success for your own FxMed Practice

Dr. Jeff Gladd is a brilliant Fx/integrative physician who is PASSIONATE about all things Fx business. Learn about FS’s integrated EMR, our Clinic Immersion and Fx Residency programs, with top tips for building your brand. And so much more. Check out the show notes for loads of links, references, downloads and more, and be sure to leave a review wherever you listen to New Frontiers! As always, thank you for listening! ~DrKF

Innovations in Clinical Laboratory Testing with Dr. Michael Chapman

Episode 74: Sponsored | Innovations in Clinical Laboratory Testing with Dr. Michael Chapman

A work horse laboratory in any functional medicine practice is stool testing. But really gleaning the best insight into our patient’s clinical picture can be tough. What do all of these commensal organisms really suggest? How do they correlate with the inflammatory findings? Of the bell weather bugs (like akkermansia) how can we increase levels? Is there ANY place for microscopy (O&P) and culture in today’s high throughput Omics world?