Polyphenols, Novel Probiotic Strains & Metabolic Health: The Latest in Microbiome Science

How much do we really know about the microbiome? What does it take to identify new probiotic strains and their associated health benefits? And is it time to move beyond single strains and into synergistic blends? I am grateful to be talking once again joined with the brilliant scientist and incredibly courageous entrepreneur Dr. Colleen Cutcliffe. With over 20 years experience managing and leading teams in biotech, pharma, and academia, I just love picking her brilliant brain! Colleen completed her postdoc research at Northwestern’s Children’s Memorial Hospital and got her PhD in biochemistry and molecular biology from John’s Hopkins, and in this episode of New Frontiers, we explore novel probiotic strains such as Clostridium bytircum, Clostridium beijerinckii & Anaerobutyricum hallii, their synergy in producing short-chain fatty acids and potential to stimulate satiety-inducing GLP-1, and so much more!

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Hydrogen Sulfide in Health, Disease & Longevity

I always appreciate a well-justified challenge to our current thinking and a chance to build a more nuanced approach that will improve patient results. And in this month’s New Frontiers in Functional Medicine® podcast, Dr. Tom Fabian delivers just that with a fascinating topic of hydrogen sulfide: a compound we clinicians typically think of as the “problem child” behind certain difficult SIBO cases. However, there is a LOT more to know about it, such as its ability to convert to potent antioxidant compounds, and its therapeutic roles in cardiovascular and metabolic disorders (diabetes and NAFLD), neurodegenerative disorders, and more.

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The Evolving Tale of the Critical Role Telomeres Provide in Aging, Senescence, and Disease

It’s always a pleasure to tap into Dr. Raffaele’s brain, and in this podcast he doesn’t disappoint. In fact, his practical contextualization of where we are with anti-aging medicine might just be one of the smartest you’ve heard yet. What is truly remarkable about Dr. Raffaele is not just his grasp of the field both scientifically and clinically, but his ability to apply a nuanced approach that is tailored to each individual patient. After all, as he eloquently points out, we must first figure out which of the many components of aging needs improvement or correction, then target our approach accordingly. The simplicity of that statement belies his firm grasp of the complex landscape of anti-aging assessments and interventions, as you’ll see.

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Latest Evidence and Clinical Applications of Akkermansia with Dr. Colleen Cutcliffe

Many of us in the functional medicine space are thinking about Akkermansia: what exactly makes this gut bug a keystone strain for health and longevity? I am excited to tackle this with a founder of Pendulum Therapeutics, Colleen Cutcliffe, PhD, an excellent scientist and a leader in biotech. Her passion to help her daughter, and many others, overcome food sensitivities inspired Colleen to use biotech and research to develop products that have the efficacy of a drug, but the safety of a probiotic. We cover it all, and then some! Enjoy, and let me know what you think. ~DrKF

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Utilizing Salivary and Urinary Hormone Testing for Comprehensive Patient Support

Folks, WOW — what a thrilling conversation on all things hormone testing with Dr. Laura Neville from Doctor’s Data! We share the same alma mater, National University of Natural Medicine, as well as extensive experience in clinical lab testing, so had lots to talk about! On this episode of New Frontiers, we discuss what different testing methods tell us about patient’s hormone status, which specimens are best for monitoring hormone replacement therapy and non-HRT interventions, why high dose progesterone carries risks, and what makes liquid urine testing stand out from the rest. Dr. Neville shares many clinical pearls from her experience reviewing thousands and thousands of tests with physicians from around the world. You’ll absolutely want to bookmark for future reference! Thanks for listening and please share, comment, and leave us a starred review if you wouldn’t mind! ~DrKF

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Strain-Specific Probiotics: Latest Evidence and Clinical Applications with Dr. Noelle Patno

What do we know about using specific probiotics for different health conditions? And is it time to move away from broad-spectrum probiotics and into condition-specific strains? With an explosion of new research on probiotics and a recent change in nomenclature, it’s easy to get confused. In this episode of New Frontiers, I lean on Dr. Noelle Patno’s extensive research knowledge to tease apart the science on probiotics. Dr. Patno holds a PhD in Molecular Metabolism and Nutrition and has designed and monitored clinical trials on microbiome and immune health. Together, we dive into the latest evidence on therapeutic uses of specific probiotic strains, including Lactobacillus rhamnosus GR-1, for women’s health and other conditions. Dr. Patno also shares excellent pearls on dosing, duration, delivery methods and antibiotic resistance. Many thanks to Noelle and the team at Metagenics for always leading the way and researching interventions.

Testosterone Therapy: Latest Evidence and Clinical Applications with Dr. Doreen Saltiel

Testosterone Therapy: Latest Evidence and Clinical Applications with Dr. Doreen Saltiel

Hormone therapy is still a highly controversial topic, fraught with lots of emotion, fear, and misleading information. And let me tell you: am I glad to be having a deep dive into the literature with my colleague and friend, the very brilliant Dr. Doreen Saltiel from Precision Analytical. She’s been practicing medicine for 40 years and preventative cardiology for more than 25 years. With advanced training in endocrinology as well as metabolic, anti-aging, and nutritional medicine, Dr. Saltiel is a leading expert on male and female hormone health. In this episode of New Frontiers, she brings her talent of dissecting the scientific evidence on testosterone deficiency and shares excellent clinical pearls to guide both physicians and patients in making decisions around hormone therapy. Folks, you’ll want to bookmark this one and save the show notes. Thanks for reading, sharing, and commenting!

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How to Fix the Vascular Health Crisis: The Endothelial Glycocalyx

We are living in times of great medical discoveries and advancements and today I am thrilled to talk about a relatively unknown structure: the endothelial glycocalyx (EGX). EGX can profoundly affect overall health – after all, you can’t have healthy organs and tissues if blood vessels are not healthy. Today on New Frontiers, I am joined by Dr. Kristine Burke a board-certified family, sports and functional medicine physician, and medical director for Help Your Diabetes Sacramento, where we discuss the full breadth of EGX functions and why it’s critical for cardiovascular health and so much more. Dr. Burke shares her exciting clinical experience and impressive findings from her case study series using Arterosil for plaque regression in some of her toughest patients. It’s a fascinating and enlightening conversation, so tune in and get ready to take some notes! Thanks for listening, and your support of New Frontiers.

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Latest Insights into the Role of the Gut Microbiome in Healthy Aging

Folks, I’m thrilled to be back once again with my friend and colleague, Dr. Tom Fabian, functional nutrition practitioner whose training originates in molecular biology of aging. Together with his training and experience as the clinical laboratory consultant for Diagnostic Solutions Lab, Dr. Fabian shares a wealth of practical applications for microbiome research in functional medicine and clinical settings. We also explore key microbial species for longevity and how to boost their levels, inflammaging of the microbiota, often-missed leaky gut clues on GI-MAP reports, the small intestine as a key site for immune tolerance, how microbiota influence epigenetics and much more. It’s truly exciting to learn from his extensive research expertise in the role of human microbiome and health, chronic disease and aging, so make sure you get ready to take notes and bookmark this page – you’ll want to come back for more! Thanks for listening, and leave us a review wherever you listen to New Frontiers! ~DrKF

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Immuno-Senescence: What Clinicians Need to Know with Dr. Joseph Raffaele

Folks, if you’ve been following me for any time, you I am fascinated with reversing epigenetic aging. With such research rapidly evolving, there’s always something new to talk about and my guest today has become a friend and a regular on the New Frontiers podcast – Dr. Joseph Raffaele: renowned expert on telomere biology and age management medicine. Dr. Raffaele, who is board-certified in internal medicine, diplomat at the American Board of Anti-Aging Medicine AND co-founder of PhysioAge Systems, joins me for the third time to talk about the latest in immunosenescence and aging. (You can find links to our previous conversations and related content in the shownotes.)