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The Evolving Tale of the Critical Role Telomeres Provide in Aging, Senescence, and Disease

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It’s always a pleasure to tap into Dr. Raffaele’s brain, and in this podcast he doesn’t disappoint. In fact, his practical contextualization of where we are with anti-aging medicine might just be one of the smartest you’ve heard yet. What is truly remarkable about Dr. Raffaele is not just his grasp of the field both scientifically and clinically, but his ability to apply a nuanced approach that is tailored to each individual patient. After all, as he eloquently points out, we must first figure out which of the many components of aging needs improvement or correction, then target our approach accordingly. The simplicity of that statement belies his firm grasp of the complex landscape of anti-aging assessments and interventions, as you’ll see.

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Latest Evidence and Clinical Applications of Akkermansia with Dr. Colleen Cutcliffe

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Many of us in the functional medicine space are thinking about Akkermansia: what exactly makes this gut bug a keystone strain for health and longevity? I am excited to tackle this with a founder of Pendulum Therapeutics, Colleen Cutcliffe, PhD, an excellent scientist and a leader in biotech. Her passion to help her daughter, and many others, overcome food sensitivities inspired Colleen to use biotech and research to develop products that have the efficacy of a drug, but the safety of a probiotic. We cover it all, and then some! Enjoy, and let me know what you think. ~DrKF

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Utilizing Salivary and Urinary Hormone Testing for Comprehensive Patient Support

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Folks, WOW — what a thrilling conversation on all things hormone testing with Dr. Laura Neville from Doctor’s Data! We share the same alma mater, National University of Natural Medicine, as well as extensive experience in clinical lab testing, so had lots to talk about! On this episode of New Frontiers, we discuss what different testing methods tell us about patient’s hormone status, which specimens are best for monitoring hormone replacement therapy and non-HRT interventions, why high dose progesterone carries risks, and what makes liquid urine testing stand out from the rest. Dr. Neville shares many clinical pearls from her experience reviewing thousands and thousands of tests with physicians from around the world. You’ll absolutely want to bookmark for future reference! Thanks for listening and please share, comment, and leave us a starred review if you wouldn’t mind! ~DrKF

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Strain-Specific Probiotics: Latest Evidence and Clinical Applications with Dr. Noelle Patno

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What do we know about using specific probiotics for different health conditions? And is it time to move away from broad-spectrum probiotics and into condition-specific strains? With an explosion of new research on probiotics and a recent change in nomenclature, it’s easy to get confused. In this episode of New Frontiers, I lean on Dr. Noelle Patno’s extensive research knowledge to tease apart the science on probiotics. Dr. Patno holds a PhD in Molecular Metabolism and Nutrition and has designed and monitored clinical trials on microbiome and immune health. Together, we dive into the latest evidence on therapeutic uses of specific probiotic strains, including Lactobacillus rhamnosus GR-1, for women’s health and other conditions. Dr. Patno also shares excellent pearls on dosing, duration, delivery methods and antibiotic resistance. Many thanks to Noelle and the team at Metagenics for always leading the way and researching interventions.

Testosterone Therapy: Latest Evidence and Clinical Applications with Dr. Doreen Saltiel

Testosterone Therapy: Latest Evidence and Clinical Applications with Dr. Doreen Saltiel

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Hormone therapy is still a highly controversial topic, fraught with lots of emotion, fear, and misleading information. And let me tell you: am I glad to be having a deep dive into the literature with my colleague and friend, the very brilliant Dr. Doreen Saltiel from Precision Analytical. She’s been practicing medicine for 40 years and preventative cardiology for more than 25 years. With advanced training in endocrinology as well as metabolic, anti-aging, and nutritional medicine, Dr. Saltiel is a leading expert on male and female hormone health. In this episode of New Frontiers, she brings her talent of dissecting the scientific evidence on testosterone deficiency and shares excellent clinical pearls to guide both physicians and patients in making decisions around hormone therapy. Folks, you’ll want to bookmark this one and save the show notes. Thanks for reading, sharing, and commenting!

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How to Fix the Vascular Health Crisis: The Endothelial Glycocalyx

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We are living in times of great medical discoveries and advancements and today I am thrilled to talk about a relatively unknown structure: the endothelial glycocalyx (EGX). EGX can profoundly affect overall health – after all, you can’t have healthy organs and tissues if blood vessels are not healthy. Today on New Frontiers, I am joined by Dr. Kristine Burke a board-certified family, sports and functional medicine physician, and medical director for Help Your Diabetes Sacramento, where we discuss the full breadth of EGX functions and why it’s critical for cardiovascular health and so much more. Dr. Burke shares her exciting clinical experience and impressive findings from her case study series using Arterosil for plaque regression in some of her toughest patients. It’s a fascinating and enlightening conversation, so tune in and get ready to take some notes! Thanks for listening, and your support of New Frontiers.

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Latest Insights into the Role of the Gut Microbiome in Healthy Aging

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Folks, I’m thrilled to be back once again with my friend and colleague, Dr. Tom Fabian, functional nutrition practitioner whose training originates in molecular biology of aging. Together with his training and experience as the clinical laboratory consultant for Diagnostic Solutions Lab, Dr. Fabian shares a wealth of practical applications for microbiome research in functional medicine and clinical settings. We also explore key microbial species for longevity and how to boost their levels, inflammaging of the microbiota, often-missed leaky gut clues on GI-MAP reports, the small intestine as a key site for immune tolerance, how microbiota influence epigenetics and much more. It’s truly exciting to learn from his extensive research expertise in the role of human microbiome and health, chronic disease and aging, so make sure you get ready to take notes and bookmark this page – you’ll want to come back for more! Thanks for listening, and leave us a review wherever you listen to New Frontiers! ~DrKF

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Immuno-Senescence: What Clinicians Need to Know with Dr. Joseph Raffaele

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Folks, if you’ve been following me for any time, you I am fascinated with reversing epigenetic aging. With such research rapidly evolving, there’s always something new to talk about and my guest today has become a friend and a regular on the New Frontiers podcast – Dr. Joseph Raffaele: renowned expert on telomere biology and age management medicine. Dr. Raffaele, who is board-certified in internal medicine, diplomat at the American Board of Anti-Aging Medicine AND co-founder of PhysioAge Systems, joins me for the third time to talk about the latest in immunosenescence and aging. (You can find links to our previous conversations and related content in the shownotes.)

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Using Metabolomic Analysis For Clinical Insight

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So many of us in functional medicine use urine organic acids as an assessment tool, yet we rarely pause to think how they are so intricately connected with the wider world of applied metabolomics. And we should because research shows that a broader view of metabolomics (i.e. not just your standard organic acid markers) results in a six-fold higher diagnosis rate compared to traditional assessment methods. Impressive, isn’t it? I’m thrilled to be joined by my dear friend and metabolomics expert Dr. Betsy Redmond in today’s podcast.

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What does “Evidence-based” look like in Functional Lab Testing?

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As the name suggests, New Frontiers is about staying ahead of the curve in functional medicine, continually asking critical questions, and being open to self-critique. This couldn’t be more true than when it comes to advanced functional testing. Today I’m pleased to talk with a familiar face and renowned hormone testing expert, my friend Mark Newman. Mark created the DUTCH test based on his decade-long experience in novel test development, and joins New Frontiers to talk about all things hormones: from cortisol & thyroid health to estrogen, progesterone and androgens, the importance of analytical and clinical validation of tests, and his upcoming research on various hormone replacement therapy methods.