In this short video blog (6 minutes, 24 seconds), Dr. Fitzgerald asks Ryan Smith, founder of TruDiagnostic, a lab that researches and specializes in understanding and reporting insights derived from epigenetic methylation data, to discuss some of the recent criticisms surrounding biological clocks.
DetailsGrip strength declines with age – this is an unwelcome change I’ve noticed even in myself, despite a good, consistent resistance training habit through adulthood. Jars that were completely uneventful for me, I need more effort to open, or resorting to using a jar-opening tool. This is in part, what makes me interested in grip strength.
DetailsCould taking a daily multivitamin actually increase mortality risk (i.e. risk of death)? This video blog takes a deep dive into the problematic research methodology of a 2024 research study on multivitamin use and mortality risk which caused a stir on popular media and news outlets.
DetailsOften, we only think of our immune system seasonally— as something we need to boost during winter months to bolster our ability to fight colds and flu. However, we should be thinking about our immune health daily as a system in our body that is susceptible to aging, just like our brains, muscles, and other critical organs. As we age, the immune system undergoes significant changes that contribute to increased vulnerability to infections and disease. Even our risk of cancer goes up with age due to a decline in immune system function. Exciting new research involving urolithin A shows a promising new way to target immune aging, offering potential strategies to maintain a more resilient immune system as we grow older.
DetailsBiological “clocks” based on epigenetic age have been around for just over a decade. Steve Horvath, a PhD scientist at UCLA launched the field with his original 2013 pan-tissue clock that predicted chronological age with head-turning accuracy. Other researchers subsequently crunched their own epigenetic (DNA methylation) data and applied advanced mathematical models to similarly predict age with their own “clocks”, resulting in a suite of available epigenetic age assessments – each with similarities but also notable differences. Some of these are more widely available for non-researchers to use than others.
DetailsWhen seeking health advice, we’ve all heard the recommendation, “start with the gut.” Whether we have high cholesterol or heavy periods, it always somehow comes back to the gut, right? Why is that? Well, it’s probably because the state of our gut affects the health of every organ system in our body, and because of this, a healthier gut tends to improve how we feel and function on a day-to-day basis. Many people only think to use a stool test to evaluate gut health, but the DUTCH Test may also yield valuable insights through its measurement of cortisol, hormone metabolites, and organic acids.
DetailsIn this 15-minute video blog segment, Dr. Fitzgerald discusses a controversial study on fish oil and cardiovascular disease that was published in the British Medical Journal earlier this year titled Regular use of fish oil supplements and course of cardiovascular diseases: prospective cohort study with former clinic resident Tish Campbell PhD. Find the study full…
DetailsIs it time to add a custom dose of vitamin D to your Younger You protocols? A small Younger You study from the UK and the importance of D more broadly suggest YES. Don’t miss thoughts on dosing (and some new data showing inadequacy of many dosing recommendations) towards the end of this article.
DetailsFrom changing the way pregnancies are planned to helping women anticipate perimenopause – female hormone trackers are here, and they’re helping clinicians provide better care for patients. This blog will take a closer look at what hormone monitors can do, how to choose the right one for your patients, and how they can help you see improved outcomes in a range of clinical scenarios.
DetailsIn this blog, we’ll take a look at how optimizing DNA methylation (through nutrition and lifestyle, as we do in Younger You), may positively impact various health conditions.
DetailsThe science and medical community has known for years that one of the biggest causes of accelerated aging is the accumulation of senescent cells. It all started back in 2015 at two of America’s top medical institutions: Mayo Clinic, and Scripps Research.
DetailsTeam DrKF sat down with Dr. Fitzgerald to pose some questions about the “state of the state” of longevity research, current controversies and future directions, and where she sees her work fitting into it. When it comes to defining and using measures of biological age, where does the science currently stand? To understand where we currently stand, and why changes are afoot, we have to first consider where we’ve come from. When Steve Horvath at UCLA released the first epigenetic biological age clock in 2013 it marked the entry of longevity medicine into the mainstream (referred to as biogerontology in science, anti-aging medicine in some clinical circles).
DetailsWhen you think about longevity tests, you might picture lipid panels and fasting blood glucose assessments. However, there’s one aspect of longevity you might not immediately consider: the health of your skin. From eczema and rosacea to premature lines and wrinkles, what’s happening on the surface is often indicative of underlying issues, including those that contribute to cardiovascular disease, dysbiosis, and mitochondrial dysfunction.
DetailsAs the name implies, spermidine was first characterized in sperm, and while there is a high concentration present in semen (and it appears important for fertility), it’s everywhere- in all eukaryotic cells. In fact, wind the evolutionary clock back to the earliest endosymbiotic happenings, you’ll find spermidine and the broader family of polyamines on center stage, playing a central role in the development of… life. Indeed, bacteria, archaea and plants (and even viruses) all rely on polyamines. These facts alone illustrate the obvious: polyamines are important. Attribution for the discovery of spermine (the polyamine metabolite of spermidine) is given to Anton Leeuwenhoek, the father of microscopy, in 1678.
DetailsIn the pursuit of wellness and longevity, skin health often mirrors the body’s internal state, serving as a visible testament to our overall well-being. Yet, traditional approaches to skincare have predominantly focused on treating the surface, neglecting the deeper cellular processes that fundamentally influence the skin’s aging and vitality. As we delve deeper into the science of longevity, a groundbreaking perspective emerges, spotlighting the crucial role of cellular and mitochondrial health not only in preserving the skin’s youthful appearance but also in maintaining the integrity of this critical organ. By shifting our focus beyond that of how we look, we can unlock new strategies for maintaining health and find a promising future where skincare transcends cosmetic concerns to embrace a holistic view of health and aging.
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