Past, Present, and Future of “Biological Aging” with Dr. Fitzgerald

Team DrKF sat down with Dr. Fitzgerald to pose some questions about the “state of the state” of longevity research, current controversies and future directions, and where she sees her work fitting into it. When it comes to defining and using measures of biological age, where does the science currently stand? To understand where we currently stand, and why changes are afoot, we have to first consider where we’ve come from. When Steve Horvath at UCLA released the first epigenetic biological age clock in 2013 it marked the entry of longevity medicine into the mainstream (referred to as biogerontology in science, anti-aging medicine in some clinical circles).

Skin care. Hands in close-up

Why Skin Health is the Ultimate Test of Longevity

When you think about longevity tests, you might picture lipid panels and fasting blood glucose assessments. However, there’s one aspect of longevity you might not immediately consider: the health of your skin. From eczema and rosacea to premature lines and wrinkles, what’s happening on the surface is often indicative of underlying issues, including those that contribute to cardiovascular disease, dysbiosis, and mitochondrial dysfunction.

medical research into spermidine

Spermidine & other polyamines: Important players in longevity? Yes… with a few caveats

As the name implies, spermidine was first characterized in sperm, and while there is a high concentration present in semen (and it appears important for fertility), it’s everywhere- in all eukaryotic cells. In fact, wind the evolutionary clock back to the earliest endosymbiotic happenings, you’ll find spermidine and the broader family of polyamines on center stage, playing a central role in the development of… life. Indeed, bacteria, archaea and plants (and even viruses) all rely on polyamines. These facts alone illustrate the obvious: polyamines are important. Attribution for the discovery of spermine (the polyamine metabolite of spermidine) is given to Anton Leeuwenhoek, the father of microscopy, in 1678.

Beyond Beauty: Targeting Skin Longevity with Urolithin A

In the pursuit of wellness and longevity, skin health often mirrors the body’s internal state, serving as a visible testament to our overall well-being. Yet, traditional approaches to skincare have predominantly focused on treating the surface, neglecting the deeper cellular processes that fundamentally influence the skin’s aging and vitality. As we delve deeper into the science of longevity, a groundbreaking perspective emerges, spotlighting the crucial role of cellular and mitochondrial health not only in preserving the skin’s youthful appearance but also in maintaining the integrity of this critical organ. By shifting our focus beyond that of how we look, we can unlock new strategies for maintaining health and find a promising future where skincare transcends cosmetic concerns to embrace a holistic view of health and aging.

holiday decorations and snowstorm

Holiday Stress – What’s in Your FxMed Toolbox?

We’ve made it successfully through the Thanksgiving rush. But do you or your patients need a set-and-refresh to make it through the rest of the holidays? The holidays are supposed to be full of cheer, family, friends, good food and good feelings, but that’s often not the case. Beyond the specter of seasonal colds and flu, patients may seek our help for another reason in December: stress. Stress can affect a multitude of biological systems, from cardiovascular to the respiratory system—but for the acute seasonal stressors like travel, family, and dietary changes, we most often see its effects on the central nervous system and the digestive system. Tension headaches, occasional trouble sleeping, indigestion and irregularity are common culprits that we can easily address with small lifestyle changes and supplementation.


Best of 2023 in Functional Medicine and Longevity

As 2023 draws to a close, here’s the content you liked most this year, and as usual it aligns with what we loved as well. Going beyond longevity and epigenetics, this year we covered a wide range of cutting-edge topics – from SPMs, urolithin A and OS-01 peptides, to nuanced thinking and recontextualizing established themes such…

Case Studies: Targeting Gut Health in Two Very Different Patient Scenarios

Dr. KF SPONSORED CONTENT I am eternally grateful to our sponsors who, by blogging, podcasting, and advertising with us, enable me and my team to devote energy and time to writing, research, and education. All the companies who sponsor us are those I trust for myself, my patients, and my fellow practitioners. Please check out…

New and Notable Studies Using Epigenetic Biological Age Clocks

This blog was written by Romilly Hodges MS CNS CDN IFMCP   Last month I was honored to be invited to speak at the American Nutrition Association annual summit on the topic Targeting Biological Age with Diet and Lifestyle. Not only was it a much-appreciated opportunity to connect face-to-face with colleagues, but it was also…

Food sources of fiber

Fiber – Are You Getting Enough to Reap its Amazing Benefits?

Only 5% men and 9% of women are getting the recommended daily amount of fiber in the United States.[1] That’s almost 90% of the population not consuming enough fiber! To put this into perspective, in 2017–18 most Americans averaged 8.1 grams of fiber for each 1,000 calories, or just 58 percent of the recommended 14 grams per 1,000 calories. Insufficient fiber intake is associated with a myriad of chronic diseases. Let’s dive into what fiber is, why it is so important, and how you can get more of it in your diet!