What Urinary Hormone Metabolite Testing Tells Us about Estrogen Metabolism and Breast Cancer Risk

What Urinary Hormone Metabolite Testing Tells Us about Estrogen Metabolism and Breast Cancer Risk

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Estrogen is a life-giving hormone with which modern humans have a complicated relationship. Over two decades ago, The Women’s Health Initiative (WHI) findings mistakenly reported that combined estrogen and progestin hormone therapy increased the risk of breast cancer, coronary heart disease, stroke, and venous thromboembolism in postmenopausal women. This led to a pervasive vilification of estrogen therapy that has affected generations of women.

The Shocking Truth About Chronic Illness: How to Reset Your Nervous System & Slow Aging

The Truth About Chronic Illness: How to Reset Your Nervous System & Slow Aging

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We’ve all had patients struggling with chronic conditions like long COVID, fibromyalgia, Lyme disease, and chronic fatigue. Despite all the tools in our functional medicine toolkit, there’s still something missing. How can we truly help them? I’m excited to have Ashok Gupta is back on the New Frontiers podcast to offer a new take on that healing from chronic illnessquestion. He explains that how many chronic diseases stem from a malfunction in the brain’s threat detection system, where the body overreacts to perceived threats, triggering immune, nervous system, or mood responses, . This creatinges a vicious cycle. Ashok shares how retraining the brain and calming the nervous system can reset the body’s response to chronic stress and presents the growing body of research supporting thehis Gupta Program, including new subjective measurements like CRP showing its impact. What excites me most is the potential for this approach to help some of my toughest-to-treat patients. With more studies emerging, I’m increasingly hopeful this could be a game-changer. It’s a conversation you won’t want to miss! ~DrKF

Next-Gen Alzheimer’s Testing: The Power of p-Tau 217 and Blood-Based Biomarkers

p-Tau 217: The Breakthrough Biomarker Revolutionizing Early Alzheimer’s Detection

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Join me for a fascinating conversation around an exciting breakthrough in dementia detection that’s offering real hope for early intervention. Dr. Hans Frykman, Chief Scientific Officer at Neurocode Laboratories, is here to share groundbreaking insights into cutting-edge biomarkers that can identify Alzheimer’s disease before symptoms even appear. What’s even more fascinating is how these same tools are revealing neuroinflammation caused by infections, including COVID, Lyme disease, and mold exposure—issues that are incredibly relevant in functional medicine today. The assays Dr. Frykman and his team have developed are transforming the way we think about diagnosing and addressing neurodegeneration. We’re talking about a potential game-changer that allows us to intervene earlier, reverse damage, and ultimately improve the trajectory of these conditions. This is an extraordinary time in science and medicine, and the work we’re discussing today is at the forefront of it all. Don’t miss out on how this could reshape your practice. ~DrKF

Exposomics and Precision Medicine: Redefining Chronic Disease with Environmental Insights

A Fresh Take on Exposomics: Resiliency Factors That Offset Environmental Risks

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In this episode, we’re diving into exposomics—one of the most cutting-edge fields in environmental medicine. We in the functional medicine space have long embraced this approach that focuses on the lifelong effects of environmental exposures, from the prenatal period on, and how these exposures shape our health over time. I’m thrilled to have Drs. Robert and Rosalind Wright with us, pioneers in this field at Mount Sinai to share their research exploring how environmental factors, from lead and air pollution to social stress, can influence chronic diseases like asthma, obesity, Alzheimer’s, and autism.

Akkermansia: A Keystone Microbe for Longevity and Metabolism

This GLP-1-Supporting Probiotic Is A Constant In Our Longevity Stack

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Join me and Dr. Colleen Cutcliffe, my brilliant friend, scientist, and the powerhouse CEO of Pendulum, for our deepest dive yet into all things Akkermansia. This free-flowing conversation will take your understanding of this extraordinary strain to a whole new level. We’ll explore Akkermansia’s pivotal role in metabolic health—think cravings, weight regulation, A1C—and why we’re deficient in the first place. Plus, we’ll discuss its connection to stress, anxiety, and even neurodegenerative diseases. We’ll also dive into the hotly debated topic of Akkermansia’s impact on MS, unpacking both sides of the controversy. And, we’ll touch on its promising influence on hormonal balance, from infertility to menopause. As someone who’s deeply invested in science, I’m personally bullish on Akkermansia and trust Pendulum’s products as part of my own foundational health stack. With groundbreaking science and fresh insights, this episode will change the way you approach your practice. ~DrKF

person tracking HRV with a smart watch

Tracking HRV: Is it Worth It?

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By the end of my book tour in 2022—one of the most amazing but intense experiences of my life—you could scrape me off the floor. (Who knew? I certainly didn’t expect it.) I was wiped out. My Oura data corroborated what I was feeling, and, particularly devastating, my HRV was stuck in the low teens. Thank goodness I’d layered an extremely needed vacation into the book experience, and we headed off to Baja California Sur. It was this vacation—and my almost immediate HRV rebound—that prompted me to trade the high-stress East Coast lifestyle for a more balanced, nurturing environment in Mexico longer term.

Healing Depression Project: Providing Hope For Treatment-Resistant Patients

Healing Depression Project: Providing Hope For Treatment-Resistant Patients

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For many struggling with depression, the message they often hear from traditional care is “just live with it” or “there’s nothing more we can do.” In today’s episode, we’re challenging that narrative. I’m joined by Dr. Achina Stein and Silvia Covelli, the founders of the Healing Depression Project. Dr. Stein, a functional psychiatrist, and Silvia, who’s personally battled chronic depression, are offering a fresh approach to treatment-resistant depression. Their in-residence program, launching in March, takes a whole-person approach—integrating nutrition, lifestyle changes, trauma healing, and community support. And with research built into the program, they’re not just helping patients; they’re also paving the way to make this approach more accessible for everyone. If you’re ready to rethink depression treatment, this episode is for you. ~DrKF

MitoQ

Is Mitochondria-Targeting the Best New Strategy for Longevity?

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Mitochondria are crucial for life, and increasingly research is finding that they hold the key to better aging and longevity, as a critical hallmark of aging. While optimising mitochondrial health through exercise, diet, and stress management is essential for maintaining their function, targeted, research-backed mitochondrial solutions are proving effective at unlocking a new level of longevity-focused results.

NAD+ in the Spotlight: New Insights on Boosting Cellular Resilience

NAD+ in the Spotlight: New Insights on Boosting Cellular Resilience

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I’m really excited about this one—Dr. Greg Kelly is back with us, and we’re diving deep into NAD, a molecule that’s finally getting the attention it deserves. If you’ve heard me talk about NAD before, you know how foundational it is for energy, longevity, and cellular health, but I’ve got to say—after today’s conversation, I’m looking at it in a whole new way. Dr. Kelly brings a fresh perspective on how NAD influences mitochondrial function, DNA repair, and even the aging process. He’s challenging the way we think about aging, and I’m here for it. For me, NAD is no longer just a side player—it’s going front and center in my supplement stack. If you’re wondering how it might show up clinically, whether it’s in fatigue or other signs of cellular stress, you’ll want to listen in. And if you’re like me, you’ll be adding this one to your regular routine. Have a listen and get ready to rethink how you approach aging and energy. ~DrKF