A recent study published by a team of scientists at Yale, UCLA, University of Florida, and University of Hawaii found that (unfortunately) experiencing violence and trauma becomes biologically embedded in our epigenome, and that these changes are passed down not just to the next generation, but to grandchildren as well.
Join me for a fascinating conversation around an exciting breakthrough in dementia detection that’s offering real hope for early intervention. Dr. Hans Frykman, Chief Scientific Officer at Neurocode Laboratories, is here to share groundbreaking insights into cutting-edge biomarkers that can identify Alzheimer’s disease before symptoms even appear. What’s even more fascinating is how these same tools are revealing neuroinflammation caused by infections, including COVID, Lyme disease, and mold exposure—issues that are incredibly relevant in functional medicine today. The assays Dr. Frykman and his team have developed are transforming the way we think about diagnosing and addressing neurodegeneration. We’re talking about a potential game-changer that allows us to intervene earlier, reverse damage, and ultimately improve the trajectory of these conditions. This is an extraordinary time in science and medicine, and the work we’re discussing today is at the forefront of it all. Don’t miss out on how this could reshape your practice. ~DrKF
We’re witnessing an exciting shift in how we understand gut health and disease—and it’s all thanks to the powerful metabolites produced by the microbiome, like short-chain fatty acids (SCFAs) and secondary bile acids. In today’s episode, Dr. Tom Fabian shares groundbreaking insights into how these postbiotics influence intestinal barrier integrity, immune balance, and even muscle regeneration. These compounds are also connected to key processes like glucose metabolism and healthy aging. What’s truly fascinating is how this science is opening up new frontiers in treating IBS, metabolic conditions, and chronic gut issues. With the upcoming launch of Diagnostic Solution Laboratories’ StoolOMX test an add-on to the GI-MAP, we now have a tool to measure these metabolites in clinical practice, making personalized and effective treatments more attainable. This is a pivotal moment in functional medicine that you don’t want to miss.
Sleepless nights can be more than just an occasional inconvenience—they often come with exhaustion, frustration, and confusion about why nothing seems to help. If you’ve (or your patients have) tried different remedies but still struggle to get quality rest, understanding the specific nature of insomnia is the key to unlocking deeper, restorative sleep.
In this episode, we’re diving into exposomics—one of the most cutting-edge fields in environmental medicine. We in the functional medicine space have long embraced this approach that focuses on the lifelong effects of environmental exposures, from the prenatal period on, and how these exposures shape our health over time. I’m thrilled to have Drs. Robert and Rosalind Wright with us, pioneers in this field at Mount Sinai to share their research exploring how environmental factors, from lead and air pollution to social stress, can influence chronic diseases like asthma, obesity, Alzheimer’s, and autism.
Join me and Dr. Colleen Cutcliffe, my brilliant friend, scientist, and the powerhouse CEO of Pendulum, for our deepest dive yet into all things Akkermansia. This free-flowing conversation will take your understanding of this extraordinary strain to a whole new level. We’ll explore Akkermansia’s pivotal role in metabolic health—think cravings, weight regulation, A1C—and why we’re deficient in the first place. Plus, we’ll discuss its connection to stress, anxiety, and even neurodegenerative diseases. We’ll also dive into the hotly debated topic of Akkermansia’s impact on MS, unpacking both sides of the controversy. And, we’ll touch on its promising influence on hormonal balance, from infertility to menopause. As someone who’s deeply invested in science, I’m personally bullish on Akkermansia and trust Pendulum’s products as part of my own foundational health stack. With groundbreaking science and fresh insights, this episode will change the way you approach your practice. ~DrKF
By the end of my book tour in 2022—one of the most amazing but intense experiences of my life—you could scrape me off the floor. (Who knew? I certainly didn’t expect it.) I was wiped out. My Oura data corroborated what I was feeling, and, particularly devastating, my HRV was stuck in the low teens. Thank goodness I’d layered an extremely needed vacation into the book experience, and we headed off to Baja California Sur. It was this vacation—and my almost immediate HRV rebound—that prompted me to trade the high-stress East Coast lifestyle for a more balanced, nurturing environment in Mexico longer term.
For many struggling with depression, the message they often hear from traditional care is “just live with it” or “there’s nothing more we can do.” In today’s episode, we’re challenging that narrative. I’m joined by Dr. Achina Stein and Silvia Covelli, the founders of the Healing Depression Project. Dr. Stein, a functional psychiatrist, and Silvia, who’s personally battled chronic depression, are offering a fresh approach to treatment-resistant depression. Their in-residence program, launching in March, takes a whole-person approach—integrating nutrition, lifestyle changes, trauma healing, and community support. And with research built into the program, they’re not just helping patients; they’re also paving the way to make this approach more accessible for everyone. If you’re ready to rethink depression treatment, this episode is for you. ~DrKF
I’m really excited about this one—Dr. Greg Kelly is back with us, and we’re diving deep into NAD, a molecule that’s finally getting the attention it deserves. If you’ve heard me talk about NAD before, you know how foundational it is for energy, longevity, and cellular health, but I’ve got to say—after today’s conversation, I’m looking at it in a whole new way. Dr. Kelly brings a fresh perspective on how NAD influences mitochondrial function, DNA repair, and even the aging process. He’s challenging the way we think about aging, and I’m here for it. For me, NAD is no longer just a side player—it’s going front and center in my supplement stack. If you’re wondering how it might show up clinically, whether it’s in fatigue or other signs of cellular stress, you’ll want to listen in. And if you’re like me, you’ll be adding this one to your regular routine. Have a listen and get ready to rethink how you approach aging and energy. ~DrKF
This month: Yes, yes, yes: intensive lifestyle interventions (4 papers); omega-3 fatty acids and exercise all WORK on preventing and/or reversing cognitive impairment, including in those with genetic risk (including APOE4). Do adipocytes house epigenetic memory leading to the inevitable weight regaining phenomenon we have long seen? The longevity potential of phytonutrients (you know I am bullish here!). And what about that wildly popular Nature Aging paper on aging happening in two bursts—am I hanging up the towel when I hit 60? (Short answer: no.)